No increase of serum autoantibodies during therapy with recombinant human interferon-beta1a in relapsing-remitting multiple sclerosis

Acta Neurologica Scandinavica
C ColosimoG Valesini

Abstract

The present investigation was aimed at establishing whether interferon (IFN)-beta would induce the synthesis of autoantibodies in patients affected by multiple sclerosis (MS). The titres of different autoantibodies were measured in a group of 68 relapsing-remitting MS patients before and during treatment with human recombinant IFN-beta1a (3 MIU or 9 MIU subcutaneously 3x a week). ANA, anti-thyroid, anticardiolipin serum autoantibodies were assayed in all cases: when patients were found positive to ANA > 1 : 40, they were also tested for anti-DNA and anti-ENA antibodies. No increase was found in autoantibodies synthesis during 6 months of r-hIFNbeta1a therapy, either at low or high dosages. The percentage of patients positive to different types of autoantibodies varied between 0 and 29%, which are values similar to those already reported in untreated MS patients. Our data indicate that the short-term use of IFN-beta1a in MS is safe in terms of the induction of humoral autoimmune responses: however, further follow-up is needed to confirm these findings during long-term treatments.

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Aug 1, 1982·Archives of Neurology·P Dore-DuffyR B Zurier
May 1, 1994·The Annals of Pharmacotherapy·J F Connelly
Sep 1, 1993·Acta Neurologica Scandinavica·T FukazawaK Tashiro

❮ Previous
Next ❯

Citations

Jan 27, 2000·Current Opinion in Rheumatology·R A Watts
May 23, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Tatiana KoudriavtsevaPaola Cordiali-Fei
Jun 29, 2000·Multiple Sclerosis : Clinical and Laboratory Research·O CiccarelliC Pozzilli
May 1, 2007·Multiple Sclerosis : Clinical and Laboratory Research·N GargM Ramanathan
Feb 15, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·A Bayas, P Rieckmann
Aug 9, 2001·Acta Neurologica Scandinavica·C de AndrésF J López Longo
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Richard W Weber
Aug 12, 2009·Muscle & Nerve
Oct 19, 2014·Lupus·I UthmanG R V Hughes
Jan 18, 2012·Multiple Sclerosis : Clinical and Laboratory Research·G GiovannoniE Waubant
May 16, 2009·Journal of Neuroimmunology·Joerg-Patrick Stübgen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.