No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
M P HawkenK P McAdam

Abstract

Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya. To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis. One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test. Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group. While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.

References

May 1, 1989·Thorax·D J BarnesJ R Turtle
Jan 1, 1986·British Journal of Diseases of the Chest·M E Ellis, F Tayoub
Dec 1, 1993·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·C H ChanC Cockram

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Citations

Feb 13, 2003·The Urologic Clinics of North America·Gilbert J Wise, Venkata K Marella
Feb 25, 2017·Microbiology Spectrum·Christopher Vinnard, Emily A Blumberg

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