No infections in 1300 anterior cruciate ligament reconstructions with vancomycin pre-soaking of hamstring grafts

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Michael PheganChristopher J Vertullo

Abstract

To investigate the pre-soaking of hamstring grafts in topical vancomycin, in addition to IV prophylaxis, during anterior cruciate ligament (ACL) reconstruction to reduce the incidence of post-operative infection, and to describe an evidence-based diagnostic and treatment algorithm to facilitate early diagnosis and appropriate management of possible knee sepsis post-operatively after ACL reconstruction. This study is a controlled observational series comprising of 1585 individuals who underwent ACL reconstruction over a 13-year period. All surgeries were performed by a single surgeon at the same hospital. Group 1 consisted of 285 patients who received pre-operative IV antibiotics without topical graft pre-soaking. Group 2 consisted of 1300 individuals who received IV antibiotics and graft pre-soaking in a vancomycin solution of 5 mg/mL. In group 1, a total of four patients suffered a post-operative joint infection (1.4 %). Three out of the four were culture positive for Staphylococcus species. The fourth was culture negative but was managed as an acute infection. Group 2 suffered no post-operative infections (0 %). Statistical analysis of the vancomycin pre-soak with IV antibiotics group, compared with IV antibiotics-alone group...Continue Reading

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Aug 16, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Karl Eriksson, Jon Karlsson
Aug 31, 2017·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Abdulaziz Z AlomarAli M Somily
Jan 19, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jan-Hendrik NaendrupThomas R Pfeiffer
Feb 7, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Victor EkdahlJesper Kraus Schmitz
Sep 10, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Michelle XiaoGeoffrey D Abrams
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