No interaction between HLA and immunoglobulin IgG heavy chain allotypes in early onset type 1 diabetes

Journal of Immunogenetics
J Bertrams, M P Baur

Abstract

Immunoglobulin heavy and light chain genes are often discussed as susceptibility genes for insulin dependent (type 1) diabetes mellitus (IDDM) in addition to HLA-DR3 and DR4. Accordingly we analysed 175 unrelated patients for an interaction between immunoglobulin allotype antigens (Gm) and HLA. While DR3 and DR4 antigens and DR3/DR4 heterozygotes occur significantly more often among diabetics than among normal controls, their Gm allotype frequencies are very similar. An interaction between special Gm allotypes and phenotypes, on the one side, and DR3, DR4 or DR3, 4 on the other side could not be demonstrated.

References

Sep 1, 1978·Tissue Antigens·N R FaridW H Marshall
Sep 1, 1984·Metabolism: Clinical and Experimental·G Schernthaner, W R Mayr
Aug 1, 1983·Journal of Immunogenetics·J BertramsE van Loghem

❮ Previous
Next ❯

Citations

Sep 1, 1991·Baillière's Clinical Endocrinology and Metabolism·L L Field
Mar 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·G F Bottazzo
Oct 1, 1986·Journal of Immunogenetics·L L Field
Jan 1, 1989·Acta Oncologica·L Dalla PalmaC Zuiani
Oct 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L GutmannJ F Acar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.