No Interaction with Alcohol Consumption, but Independent Effect of C12orf51 (HECTD4) on Type 2 Diabetes Mellitus in Korean Adults Aged 40-69 Years: The KoGES_Ansan and Ansung Study

PloS One
Jihye KimMi Kyung Kim

Abstract

Previously, genetic polymorphisms of C12orf51 (HECTD4) (rs2074356 and/or rs11066280) have been shown to be related to alcohol consumption and type 2 diabetes (T2D). This study aimed to prospectively examine whether C12orf51 had an interaction with or independent effect on alcohol consumption and the risk of T2D. The present study included 3,244 men and 3,629 women aged 40 to 69 years who participated in the Korean Genome and Epidemiology Study (KoGES)_Ansan and Ansung Study. Cox proportional hazards models were used to estimate HRs and 95% CIs for T2D. rs2074356 and rs11066280 were associated with the risk of T2D after adjusting for alcohol consumption (rs2074356 for AA: HR = 0.39 and 95% CI = 0.17-0.87 in men, and HR = 0.36 and 95% CI = 0.13-0.96 in women; rs11066280 for AA: HR = 0.44 and 95% CI = 0.23-0.86 in men, and HR = 0.39 and 95% CI = 0.16-0.94 in women). We identified that the association of each variant (rs2074356 and rs11065756) in C12orf51 was nearly unchanged after adjusted for alcohol consumption. Therefore, the association of 2 SNPs in C12orf51 with diabetes may not be mediated by alcohol use. There was no interaction effect between alcohol consumption and the SNPs with T2D. However, even in never-drinkers, minor...Continue Reading

References

Apr 15, 1991·American Journal of Epidemiology·E GiovannucciW C Willett
Mar 19, 1994·Lancet·S HiguchiH Kono
May 1, 1996·Alcoholism, Clinical and Experimental Research·S HiguchiM Hayashida
Jun 19, 2001·Alcoholism, Clinical and Experimental Research·K OkamotoH Kawasaki
Jul 11, 2006·Psychological Bulletin·Susan E LuczakTamara L Wall
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jan 30, 2008·Archives of Internal Medicine·Inkyung BaikChol Shin
Jun 19, 2008·International Journal of Clinical Practice·N FreemantleS Kumar
Sep 30, 2008·Cellular and Molecular Neurobiology·Lisheng ZhangNian Zhang
Oct 31, 2009·Diabetes Care·Dolly O BaliunasJürgen Rehm
Oct 26, 2010·Diabetes Research and Clinical Practice·Tao ChenHaoming Tian
Jan 29, 2011·The American Journal of Clinical Nutrition·Inkyung BaikChol Shin
Feb 1, 2013·The American Journal of Clinical Nutrition·Xueli YangDongfeng Gu
Apr 11, 2013·BMJ : British Medical Journal·Walter C Willett
Dec 3, 2013·Diabetes Research and Clinical Practice·UNKNOWN International Diabetes Federation
Jan 3, 2014·Physiological Reviews·Che-Hong ChenDaria Mochly-Rosen

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Citations

Apr 9, 2017·Stroke; a Journal of Cerebral Circulation·Sun Ju LeeSun Ha Jee
Sep 4, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Stefan DietrichMatthias B Schulze
Aug 4, 2018·Korean Circulation Journal·Keum Ji JungSun Ha Jee

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Methods Mentioned

BETA
genotyping
ubiquitination

Software Mentioned

SAS
Affymetrix

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