PMID: 15240670Jul 9, 2004Paper

No intrinsic deficiencies in CD8+ T cell-mediated antitumor immunity with aging

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lyse A Norian, Paul M Allen

Abstract

Aging is associated with a decline in immune function, particularly within the T cell compartment. Because CD8(+) T cells are critical mediators of protective immunity against cancer, which arises more frequently with advancing age, it is important to understand how aging affects T cell-based antitumor responses. We used our DUC18 T cell/CMS5 tumor model system to examine the ability of both aged APCs and aged, tumor-specific CD8(+) T cells to mount protective responses to tumors in vivo. An assessment of aged DUC18 T cells in vitro showed a naive phenotype, but impaired proliferation in response to anti-CD3 and anti-CD28 stimulation. We found that DCs from young and old recipient mice are comparable phenotypically, and endogenous APCs in these mice are equally able to prime adoptively transferred young DUC18 T cells. Even when aged DUC18 T cells are transferred into aged CMS5-challenged mice, Ag-specific proliferation and CD25 expression are similar to those found when young DUC18 T cells are transferred into young mice. Although trafficking to tumor sites appears unequal, old and young DUC18 T cells reject primary CMS5 challenges to the same degree and with similar kinetics. Overall, we found no loss of endogenous APC functio...Continue Reading

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Citations

Nov 2, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Annabelle Grolleau-JuliusRaymond L Yung
Sep 11, 2007·Cancer Immunology, Immunotherapy : CII·Sanjay SharmaJoseph Lustgarten
Dec 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristin R RenkemaJanko Nikolich-Žugich
Jun 30, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Britnie R JamesLyse A Norian
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bo-Chin ChiuStephen W Chensue

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