No long-term increase in cardiac-related mortality after breast-conserving surgery and radiation therapy using modern techniques

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A J NixonJ R Harris

Abstract

To determine whether left-breast irradiation using modern techniques after breast-conserving surgery leads to an increased risk of cardiac-related mortality. Between 1968 and 1986, 1,624 patients were treated for unilateral stage I or II breast cancer at the Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, with conservative surgery and breast irradiation. Seven hundred forty-five patients with a potential follow-up of at least 12 years were analyzed. Clinical, pathologic, and treatment characteristics were compared between the 365 patients (49%) who received left-sided irradiation and the 380 patients (51%) who received right-sided irradiation. The relationship between left-sided breast irradiation and the risk of nonbreast cancer- and cardiac-related mortality was examined. There was no significant difference in the distribution of clinical, pathologic, or treatment characteristics between the two groups, with the exception of a small difference in pathologic tumor size (medians, left, 2.0 cm, right, 1.5 cm; P = .007). At 12 years, a majority of patients still were alive. Slightly more patients with left-sided tumors had died of breast cancer (31% v 27%; P = NS). Equivalent proportions from each group di...Continue Reading

Citations

Nov 5, 1999·Current Opinion in Oncology·F Asrari, I Gage
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LohrischI A Olivotto
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rinaa S PungliaAbram Recht
Mar 17, 2005·Journal of the National Cancer Institute·Sharon H GiordanoJames S Goodwin
Apr 13, 2005·Pediatric Blood & Cancer·Javier Jurado, Paul D Thompson
Feb 10, 2007·Expert Review of Anticancer Therapy·Shannon M Macdonald, Alphonse G Taghian
Jul 24, 2014·Radiation Oncology·Jean-Michel CaudrelierKayvan Amjadi
May 23, 2017·Journal of the American Heart Association·Yun-Jiu ChengSu-Hua Wu
Nov 10, 2018·Cardiology Research and Practice·Christopher DeZorzi
Feb 6, 2020·International Journal of Cancer. Journal International Du Cancer·Katherine E HensonCarolyn W Taylor
Sep 15, 2000·Acta Oncologica·R Arriagada, M G Lê
Oct 12, 2000·The New England Journal of Medicine·H J Burstein, E P Winer
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ZambettiL Gianni
May 27, 2004·Radiation Research·Michiko YamadaGen Suzuki
Aug 16, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Abram Recht
Oct 16, 2004·The British Journal of Radiology·J A Violet, C Harmer
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lori J Pierce
May 24, 2012·Breast Care·Cordula Petersen, Florian Würschmidt
Oct 20, 2011·Journal of Medical Imaging and Radiation Oncology·Wei WangJohn Boyages
Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Debra A PattSharon H Giordano
Mar 8, 2007·Journal of the National Cancer Institute·Maartje J HooningFlora E van Leeuwen
Jun 30, 2001·The New England Journal of Medicine·C L Shapiro, A Recht
Mar 11, 2004·The British Journal of Radiology·K VenablesP J Hoskin
Apr 1, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Eleanor E Harris
Aug 16, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleanor E R HarrisLawrence J Solin
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph R CarverUNKNOWN ASCO Cancer Survivorship Expert Panel
Jun 12, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marc D PirothMichael J Eble
Jan 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Abram Recht
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A RechtUNKNOWN American Society of Clinical Oncology
Dec 28, 1999·Medical and Pediatric Oncology·E E Harris, L J Solin
Apr 24, 2014·Current Treatment Options in Cardiovascular Medicine·Margot Davis, Ronald M Witteles
Sep 29, 2015·Epidemiology·Patrick T BradshawMarilie D Gammon
Apr 17, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frank LohrFrederik Wenz
Feb 16, 2002·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Tsuguhiro MiyashitaKazuo Shimizu
Jun 2, 2014·Orvosi hetilap·Tamás NagykálnaiLászló Landherr

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