PMID: 16618241Apr 19, 2006Paper

No longer a biological waste product: umbilical cord blood

The Medical Journal of Australia
T A O'BrienM Vowels

Abstract

Haematopoietic stem cell transplantation is an accepted curative therapy for many cancers and inherited non-malignant diseases, including bone marrow failure syndromes, haemoglobinopathies, and inborn errors of metabolism. Stem cells can be used from the bone marrow or blood of matched siblings or appropriately matched unrelated volunteers, but many patients do not have a suitably matched donor. Umbilical cord blood (UCB) has been successfully used as an alternative stem cell source. It has the advantage of tolerance for a degree of human leukocyte antigen (HLA) incompatibility not possible with adult bone marrow, resulting in greater likelihood of finding an appropriate match. UCB is also stored fully tested and cryopreserved, leading to rapid availability. Greatest clinical experience in UCB transplants has been in treating paediatric leukaemia. Results using well matched UCB grafts are equivalent or better than with unrelated bone marrow transplant. Cell dose and the degree of HLA matching are critical determinants in the success of UCB transplant. The use of UCB in older children and adult patients has been limited by the fixed, low cell dose available in a UCB unit, relative to recipient weight. This can be overcome by str...Continue Reading

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H E BroxmeyerE A Boyse
Nov 14, 1997·Current Opinion in Hematology·D L Confer
Jun 18, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Juliet N BarkerDaniel J Weisdorf
Aug 13, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elizabeth J ShpallIan K McNiece
Nov 9, 2002·Blood·Franco LocatelliUNKNOWN Eurocord Transplant Group
May 7, 2004·The New England Journal of Medicine·Susan L StabaJoanne Kurtzberg
Sep 11, 2004·Biochemical and Biophysical Research Communications·Norman EndeAlluru S Reddi
Nov 27, 2004·The New England Journal of Medicine·Mary J LaughlinMary M Horowitz
Nov 27, 2004·The New England Journal of Medicine·Vanderson RochaUNKNOWN Eurocord-Netcord Registry

❮ Previous
Next ❯

Citations

Dec 25, 2007·Regenerative Medicine·Catalina A PalmaBernard E Tuch
Sep 8, 2020·Neuromolecular Medicine·Zi-Xuan WangAng Xing
Nov 28, 2012·Journal of Bioethical Inquiry·Maree PorterChristopher F C Jordens
Feb 25, 2010·The Journal of Obstetrics and Gynaecology Research·Atsuko OmoriIkuo Kashiwakura
Dec 3, 2016·Pediatric Blood & Cancer·Seyed Hadi MousaviMona Ahmadipanah
Oct 27, 2017·Experimental and Therapeutic Medicine·Hao ZhangHu Chen
Jun 7, 2007·Tissue Engineering·Lye T Lock, Emmanuel S Tzanakakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.