No major association between TGFBR1*6A and prostate cancer

BMC Genetics
Virginia G KaklamaniBoris Pasche

Abstract

Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. TGFBR1*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that TGFBR1*6A may contribute to the development of prostate cancer. TGFBR1*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer.

References

Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·T ChenM Reiss
Dec 11, 2002·American Journal of Human Genetics·Stephen M EdwardsUNKNOWN British Association of Urological Surgeons Section of Oncology
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Virginia G KaklamaniBoris Pasche
Oct 15, 2003·Nature Reviews. Cancer·Peter M Siegel, Joan Massagué
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Boris PascheTongzhang Zheng
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Feb 22, 2012·World Journal of Gastrointestinal Oncology·Laura Valle
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hong-Tao ZhangXiao-Feng Chen
Jul 30, 2008·Cell·Joan Massagué

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Methods Mentioned

BETA
biopsy
PCR

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