No Major Effect of Innate Immune Genetics on Acute Kidney Rejection in the First 2 Weeks Post-Transplantation

Frontiers in Pharmacology
Rong HuAndrew A Somogyi

Abstract

Innate immunity contributes to acute rejection after kidney transplantation. Genetic polymorphisms affecting innate immunity may therefore influence patients' risk of rejection. IL2 -330T > G, IL10 -1082G > A, -819C > T, and -592C > A, and TNF -308G > A are not associated with acute rejection incidence in Caucasian kidney transplant recipients receiving a calcineurin inhibitor, ciclosporin or tacrolimus (TAC). However, other important innate immune genetic polymorphisms have not yet been extensively studied in recipients and donors. In addition, innate immunogenetics have not been investigated in kidney transplant cohorts receiving only TAC as the calcineurin inhibitor. To investigate the effect of recipient and donor CASP1, CRP, IL1B, IL2, IL6, IL6R, IL10, MYD88, TGFB, TLR2, TLR4, and TNF genetics on acute kidney rejection in the first 2 weeks post-transplant in TAC-treated kidney transplant recipients. This study included 154 kidney transplant recipients and 81 donors successfully genotyped for 17 polymorphisms in these genes. All recipients were under triple immunosuppressant therapy of TAC, mycophenolate mofetil, and prednisolone. Recipient and donor genotype differences in acute rejection incidence within the first 2 weeks...Continue Reading

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J KosturaJ A Schmidt
Oct 27, 1994·The New England Journal of Medicine·UNKNOWN U.S. Multicenter FK506 Liver Study Group
Feb 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D M TurnerI V Hutchinson
Apr 1, 1997·Molecular Immunology·K M KroegerL J Abraham
Jan 15, 1999·Human Molecular Genetics·D J GraingerT D Spector
Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
Feb 21, 2004·Immunity·Patrick T WalshLaurence A Turka
May 11, 2005·Kidney International·Didier DuclouxPierre Tiberghien
Jun 2, 2005·Nature Reviews. Immunology·Foo Y LiewLuke A J O'Neill
Mar 17, 2007·Transplantation Proceedings·E NogueiraA Pacheco-Silva
Jan 1, 2008·Molecular and Cellular Biochemistry·Parmeet Kaur Manchanda, Rama Devi Mittal
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vijay SaxenaRam Raj Singh
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezM Valente
Mar 22, 2008·Clinical Chemistry·Andrew J P SmithSteve E Humphries
Oct 12, 2010·The New England Journal of Medicine·Brian J Nankivell, Stephen I Alexander
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Sep 11, 2012·European Journal of Clinical Pharmacology·Diana Lacruz-GuzmánPablo Conesa-Zamora
Aug 3, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rumi TaniguchiNaoki Inoue
Dec 20, 2013·Journal of Molecular Neuroscience : MN·Claire Vignette MulhollandJames Wallace Sleigh
Apr 26, 2014·Journal of the American Society of Nephrology : JASN·Hans-Joachim Anders, Liliana Schaefer
Jul 6, 2014·Cytokine·Janina WolfChristoph Garbers
Dec 1, 1980·Immunology Today·J WatsonS Gillis
Oct 17, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Janet K CollerJoanne M Bowen
Dec 4, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·SIqing DingQiquan Wan
Jan 7, 2017·Journal of Immunology Research·Lan ZhuGang Chen

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Methods Mentioned

BETA
genotyping

Software Mentioned

GraphPad Prism
GraphPad

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