No major influence of regular tobacco smoking on cerebrospinal fluid monoamine metabolite concentrations in patients with psychotic disorder and healthy individuals

Psychiatry Research
Josefin HjärpeErik G Jönsson

Abstract

Metabolism of the monoamines dopamine, serotonin and noradrenaline, is altered in the central nervous system of people with schizophrenia, and their major metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), respectively, have been intensively studied as indirect measures of these neurotransmitters in cerebrospinal fluid (CSF). Regular tobacco smoking has been shown to alter neurotransmitter metabolism in the brain and studies have found CSF monoamine metabolite concentrations to be substantially lower in smokers. However, few studies investigating these monoamines in CSF have controlled for regular tobacco smoking. We investigated if regular tobacco smoking influences CSF HVA, 5-HIAA and MHPG concentrations in patients treated for psychotic disorders (n = 69) and healthy non-psychotic human volunteers (n = 200). After lumbar puncture CSF samples were analyzed with mass fragmentography. CSF HVA, 5-HIAA and MHPG concentrations did not significantly differ between smokers and non-smokers neither in patients, nor in healthy subjects, whereas back-length predicted HVA and 5-HIAA and antipsychotic medication MHPG concentrations. The results indicate that regular tobacco...Continue Reading

References

Jul 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·R SjöströmE Anggård
Sep 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·L BjerkenstedtF A Wiesel
Jan 1, 1973·The American Journal of Psychiatry·R M PostE K Gordon
Jan 1, 1970·Brain : a Journal of Neurology·A T MoirH C Guldberg
Dec 1, 1982·Archives of General Psychiatry·C NordinL Bertilsson
Mar 1, 1984·Acta Psychiatrica Scandinavica·M AsbergL Träskman-Bendz
Aug 1, 1993·Archives of General Psychiatry·J K HsiaoD Pickar
Nov 15, 1996·Biological Psychiatry·E JönssonF A Wiesel
Jan 19, 1999·The American Journal of Psychiatry·T D GeraciotiA B Norman
Sep 15, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F E ScheepersR S Kahn
Apr 2, 2003·The American Journal of Psychiatry·Kevin M MaloneJ John Mann
Mar 28, 2008·Expert Review of Molecular Diagnostics·Emanuel Schwarz, Sabine Bahn
Nov 4, 2008·Journal of Affective Disorders·Hanga GalfalvyJ John Mann
Jul 5, 2011·Neuroscience and Biobehavioral Reviews·Henri-Jean AubinGeorg Winterer
Mar 29, 2012·European Archives of Psychiatry and Clinical Neuroscience·Dimitrios AndreouErik G Jönsson
Apr 5, 2012·Archives of General Psychiatry·Oliver D HowesShitij Kapur
Dec 10, 2013·Lancet·Oliver D Howes, Robin M Murray
Jan 19, 2016·Lancet·Michael J OwenPreben B Mortensen
Jul 28, 2017·The Journal of Clinical Psychiatry·Hyung Shin YoonHiroshi Kunugi

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