No modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS)

Scientific Reports
Marius KeuteTino Zaehle

Abstract

Transcutaneous auricular vagus nerve stimulation (taVNS) bears therapeutic potential for a wide range of medical conditions. However, previous studies have found substantial interindividual variability in responsiveness to taVNS, and no reliable predictive biomarker for stimulation success has been developed so far. In this study, we investigate pupil size and event-related pupil response as candidate biomarkers. Both measures have a direct physiological link to the activity of the locus coeruleus (LC), a brainstem structure and the main source of norepinephrine in the brain. LC activation is considered one of the key mechanisms of action of taVNS, therefore, we expected a clear increase of the pupillary measures under taVNS compared to sham (placebo) stimulation, such that it could serve as a prospective predictor for individual clinical and physiological taVNS effects in future studies. We studied resting pupil size and pupillary responses to target stimuli in an auditory oddball task in 33 healthy young volunteers. We observed stronger pupil responses to target than to standard stimuli. However, and contrary to our hypothesis, neither pupil size nor the event-related pupil response nor behavioral performance were modulated b...Continue Reading

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Citations

Dec 23, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Yu WangPeijing Rong
Jan 15, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Uirassu BorgesMarkus Raab
Mar 23, 2021·Nature Communications·Zakir MridhaMatthew James McGinley
May 25, 2021·Journal of Vestibular Research : Equilibrium & Orientation·Alexander Hui Xiang YangYusuf Ozgur Cakmak
May 21, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marius KeuteTino Zaehle
Jun 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fioravante CaponeVincenzo Di Lazzaro
Jun 24, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Mikołaj Tytus Szulczewski
Aug 1, 2021·Behaviour Research and Therapy·Stefanie De SmetMarie-Anne Vanderhasselt

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