No need for frame-wise attenuation correction in dynamic Rubidium-82 PET for myocardial blood flow quantification

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
J D van DijkJ A van Dalen

Abstract

Regadenoson-induced stress causes a repositioning of the heart, myocardial creep, in half of the patients undergoing Rubidium-82 (Rb-82) positron emission tomography (PET). As a result, misalignment of dynamic PET and computer tomography (CT) may occur, possibly affecting CT-based attenuation correction (AC) and thereby PET-based myocardial blood flow (MBF) quantification. Our aim was to determine the need for frame-wise PET-CT AC to obtain reliable MBF measurements. 31 Out of 64 consecutive patients had myocardial creep during regadenoson-induced stress Rb-82 PET-CT and were included. Prior to PET image reconstruction, we applied two AC methods; single PET-CT alignment and frame-wise alignment in which PET time-frames with myocardial creep were individually co-registered with CT. The PET-CT misalignment was then quantified and MBFs for the three vascular territories and whole myocardium were calculated and compared between both methods. The magnitude of misalignment due to myocardial creep was 13.8 ± 4.5 mm in caudal-cranial direction, 1.8 ± 2.1 mm in medial-lateral and 2.5 ± 1.8 mm in anterior-posterior direction. Frame-wise PET-CT registration did not result in different MBF measurements (P ≥ .07) and the magnitude of misali...Continue Reading

References

Sep 5, 2006·Journal of the American College of Cardiology·Keiichiro YoshinagaRob S B Beanlands
Dec 19, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ludovic Le MeunierStephen L Bacharach
Jun 9, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert A deKempRob S B Beanlands
Jun 19, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·K Lance GouldStefano Sdringola
Jul 10, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Mireille LortieRobert A DeKemp
Mar 15, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maria C ZiadiRob S B Beanlands
Oct 24, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mahadevan RajaramPaco E Bravo
Mar 13, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stephan G Nekolla, Axel Martinez-Möller
Mar 24, 2015·JACC. Cardiovascular Imaging·Nils P Johnson, K Lance Gould
Feb 6, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Roberto SciagràUNKNOWN Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)
Jul 10, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vasken DilsizianMark I Travin
Nov 3, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ran KleinRobert A deKemp
Jan 6, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthew J MemmottParthiban Arumugam
Dec 16, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Venkatesh L MurthyJames R Corbett
Mar 25, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Benjamin C LeeVenkatesh L Murthy
Mar 27, 2018·Current Cardiology Reports·Marina PiccinelliErnest V Garcia
Feb 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ A van Dalen

❮ Previous
Next ❯

Citations

Feb 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ A van Dalen
Mar 29, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Elia von Felten, Andreas A Giannopoulos
Sep 22, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Martin Lyngby Lassen, Piotr J Slomka
Aug 8, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
May 23, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
May 16, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ D van Dijk
Feb 21, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
Mar 23, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Benjamin C Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.