PMID: 16613571Apr 15, 2006Paper

NO-NSAIDs: from inflammatory mediators to clinical readouts

Inflammation & Allergy Drug Targets
Stefano Fiorucci, Elisabetta Antonelli

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase (COX)-2 selective inhibitors (COXIBs) are widely used drugs. However, their use is hampered by gastrointestinal, cardiovascular and renal side effects. Nitric oxide (NO)-releasing NSAIDs, NO-NSAID, are a new class of anti-inflammatory and analgesic drugs generated by adding a nitroxybutyl or a nitrosothiol moiety to the parent NSAID via a short-chain ester linkage. While efficacy of nitrosothiol-NSAIDs still awaits investigation, nitroxybutyl-NO-NSAIDs have been extensively studied in humans. The combination of balanced inhibition of the two main COX isoforms with release of NO confers to NO-NSAIDs reduced gastrointestinal and cardiorenal toxicity. It is suggested that the NO, which is released as the compounds are broken down, may counteract the consequences of the NSAID-induced decrease in gastric mucosal prostaglandins. Recent clinical trials with NO-NSAIDs have provided data consistent with pre-clinical observations.

Citations

Apr 26, 2007·Clinical Medicine & Research·C K S OngR A Seymour
Nov 26, 2011·Expert Review of Clinical Pharmacology·Xianfeng Gu, Yi Zhun Zhu
May 19, 2009·Gastroenterology Clinics of North America·Stefano Fiorucci
Nov 13, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S FiorucciE Distrutti
Sep 27, 2007·CNS Drug Reviews·E Alfonso Romero-SandovalJuan F Herrero
Feb 11, 2015·Free Radical Biology & Medicine·Debashree BasudharKatrina M Miranda

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