No parallel fiber volleys in the cerebellar cortex: evidence from cross-correlation analysis between Purkinje cells in a computer model and in recordings from anesthetized rats

Journal of Computational Neuroscience
Dieter Jaeger

Abstract

Purkinje cells aligned on the medio-lateral axis share a large proportion of their approximately 175,000 parallel fiber inputs. This arrangement has led to the hypothesis that movement timing is coded in the cerebellum by beams of synchronously active parallel fibers. In computer simulations I show that such synchronous activation leads to a narrow spike cross-correlation between pairs of Purkinje cells. This peak was completely absent when shared parallel fiber input was active in an asynchronous mode. To determine the presence of synchronous parallel fiber beams in vivo I recorded from pairs of Purkinje cells in crus IIa of anesthetized rats. I found a complete absence of precise spike synchronization, even when both cells were strongly modulated in their spike rate by trains of air-puff stimuli to the face. These results indicate that Purkinje cell spiking is not controlled by volleys of synchronous parallel fiber inputs in the conditions examined. Instead, the data support a model by which granule cells primarily control Purkinje cell spiking via dynamic population rate changes.

Citations

Dec 1, 2006·The Cerebellum·Mario-Ubaldo Manto
Apr 28, 2011·The Journal of Physiology·Marylka Uusisaari, Erik De Schutter
Jan 15, 2014·Nature Neuroscience·Antonin Blot, Boris Barbour
Nov 13, 2014·PloS One·Claudia CasellatoEgidio D'Angelo
Sep 22, 2006·Journal of Neurophysiology·Soon-Lim Shin, Erik De Schutter
Jun 4, 2019·Frontiers in Computational Neuroscience·Lingling AnJian K Liu
Jul 28, 2016·ELife·Sungho HongErik De Schutter
Dec 23, 2004·The Journal of Physiology·Wolfgang MittmannMichael Häusser

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