PMID: 3768344Sep 9, 1986Paper

No phospholipid monolayer-sugar interactions

Biochemistry
E M ArnettD Chapman

Abstract

Studies by a number of workers using the Langmuir film balance have shown that when carbohydrates, such as sucrose or glycerol, are dissolved in a subphase on which a phospholipid is spread, film expansion occurs (Cadenhead & Demchak, 1969; Cadenhead & Bean, 1972; Maggio et al., 1976; Maggio & Lucy, 1978). Recently such effects have been observed again, particularly with the carbohydrates galactose and trehalose (Johnston et al., 1984). The origin of these film expansions was uncertain, and various suggestions have been made to explain them. One idea was that they might be due to interactions which these carbohydrates have with the water molecules close to the polar head groups of the lipids. Recent studies in our two laboratories, described here, show that the magnitude of the expansion effects is variable and that in general they arise from surfactant impurities in the sugars. These impurities are observed in carbohydrates which are reputedly of high grade; the amount of impurity present can vary from batch to batch, and sometimes they can be difficult to remove. Film balance techniques or subphase preparation can mask the detection of minor impurities. The presence of surfactant impurities in reputedly pure carbohydrates nee...Continue Reading

Citations

Jun 9, 1988·Biochimica Et Biophysica Acta·J H CroweT J Anchordoguy
May 9, 2001·Biochimica Et Biophysica Acta·I J VereykenB De Kruijff
Feb 28, 1997·Biophysical Chemistry·G Xie, S N Timasheff
Aug 1, 1991·Cryobiology·L S Bakás, E A Disalvo
Jan 18, 1993·Biochimica Et Biophysica Acta·L I VieraE A Disalvo
Oct 10, 1998·Biochimica Et Biophysica Acta·R A DemelB de Kruijff
Sep 28, 1989·Biochimica Et Biophysica Acta·J C Mathai, V Sitaramam
Jun 1, 1988·Journal of Biomolecular Structure & Dynamics·I Chandrasekhar, B P Gaber
Oct 24, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Claire AlbertFlorence Agnely
Aug 25, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Marcos Ariel VillarrealGuillermo G Montich

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