Abstract
Dendritic cells (DCs) are the most efficient antigen-presenting cells and play a role in immune reconstitution after autologous transplantation. Recent reports suggest that mobilization with granulocyte colony-stimulating factor (G-CSF) containing regimens polarizes DCs into pDC2, which could potentially result with increased Th2 response and decreased graft-versus-host disease (GVHD) in allogeneic transplantation and with decreased cytotoxic Th1 response and graft versus tumor effect, which in autologous transplantation could translate into increased relapse rate. Previously, we have shown that non-Hodgkin's lymphoma (NHL) patients receiving cyclophosphamide (CTX) plus granulocyte- macrophage (GM)-CSF, G-CSF or GM-CSF followed by G-CSF for stem cell collection, mobilize up to five-fold more mature CD80(+) DCs compared to CTX plus G-CSF mobilized patients. Here, we analyzed samples from the same study for the number of pDC1 and pDC2 subsets in blood and apheresis products obtained from these patients. Samples from 29 patients were collected. Patients mobilized with CTX plus G-CSF collected a mean of 1.2 +/- 0.4 x 10(6) pDC1/kg per day and 2.2 +/- 1 x 10(6) pDC2/kg per day, whereas patients mobilized with CTX plus GM-CSF collect...Continue Reading
References
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W BensingerC Weaver
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J WattsD C Linch
Jun 11, 1998·Journal of Hematotherapy·C H WeaverC D Buckner
Aug 6, 1998·American Journal of Hematology·G D'ArenaM Carotenuto
Jun 1, 1999·Journal of Hematotherapy·Y GazittW Montgomery
Jan 25, 2000·Journal of Hematotherapy & Stem Cell Research·M A MorseH K Lyerly
Nov 10, 2000·Stem Cells·Y Gazitt
Nov 25, 2000·Journal of Hematotherapy & Stem Cell Research·Y GazittP Devore
Mar 29, 2001·Journal of Hematotherapy & Stem Cell Research·Y GazittP Devore
Apr 13, 2001·Experimental Hematology·H TayebiE Robinet
May 22, 2001·Journal of Hematotherapy & Stem Cell Research·Y Gazitt
Mar 27, 2002·Nature Reviews. Immunology·Ken Shortman, Yong-Jun Liu
Apr 16, 2002·Current Opinion in Hematology·Yair Gazitt
May 29, 2002·Experimental Hematology·Phennapha Klangsinsirikul, Nigel H Russell
Nov 20, 2002·Bone Marrow Transplantation·B D HockJ L McKenzie
Mar 29, 2003·Cancer Immunology, Immunotherapy : CII·Silvia FerrariMarco Danova
Aug 28, 2003·Cancer Immunology, Immunotherapy : CII·Malcolm S Mitchell
Jan 31, 2004·Seminars in Immunology·Kiyoshi Takeda, Shizuo Akira
Feb 12, 2004·British Journal of Haematology·Joaquín SánchezMiguel A Alvarez
Apr 8, 2004·Blood·Eiko ShimizuMasaru Taniguchi
Aug 21, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Luke R ShierStephen Couban
Dec 1, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sagar LonialEdmund K Waller
Citations
Nov 19, 2009·Cancer Immunology, Immunotherapy : CII·Mohamed Labib Salem, David J Cole
Jun 19, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chengzhong FanAbass Alavi
Dec 29, 2009·Cellular Immunology·Mohamed L SalemDavid J Cole
Nov 3, 1996·Transfusion Science·H KasparuD Lutz
Sep 6, 2007·Stem Cells and Development·Yair GazittGary Calandra
Nov 11, 2010·Journal of Translational Medicine·Giuseppina BonannoSergio Rutella
Mar 1, 2008·Biologics : Targets & Therapy·Martha Arellano, Sagar Lonial
Jul 16, 2009·Leukemia & Lymphoma·Julie M VoseJohn Dipersio
May 26, 2011·Cytotherapy·Erika Adriana EksiogluVijay Reddy
Jul 11, 2006·Stem Cells·Paul J ShaughnessyYair Gazitt
Jul 20, 2010·British Journal of Haematology·Morie A Gertz
Dec 4, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sagar LonialEdmund K Waller
Feb 11, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stefan Fruehauf, Guido Tricot
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed L SalemDavid J Cole
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed L SalemDavid J Cole