No question about exciting questions in cell biology

PLoS Biology
Thomas D Pollard

Abstract

Although we have a good grasp of many important processes in cell biology, including knowledge of many molecules involved and how they interact with each other, we still do not understand most of the dynamical features that are the essence of living systems. Fortunately, we now have the ability to dissect biological systems in enough detail to understand their dynamics, including the use of mathematical models to account for past observations and predict future experiments. This deep level of mechanistic understanding should be our goal—not simply to satisfy our scientific curiosity, but also to understand the causes of disease well enough to predict risks, make early diagnoses, and treat effectively. Many big questions remain to be answered before we reach this goal of understanding cellular dynamics.

References

Oct 15, 2005·Science·Jian-Qiu Wu, Thomas D Pollard
Dec 15, 2007·Science·Dimitrios VavylonisThomas D Pollard
Dec 1, 2010·Molecular Biology of the Cell·Thomas D Pollard
Nov 16, 2011·The Journal of Cell Biology·Valerie C CoffmanJian-Qiu Wu
Nov 16, 2011·The Journal of Cell Biology·Josh LawrimoreE D Salmon
Apr 13, 2013·Molecular Biology of the Cell·Thomas D Pollard, Enrique M De La Cruz
May 15, 2013·Trends in Biotechnology·Thomas GajCarlos F Barbas

❮ Previous
Next ❯

Citations

Aug 16, 2014·Current Opinion in Chemical Biology·Germán RivasPetra Schwille
Aug 1, 2015·Molecular Biology of the Cell·Peter-G Barr-Gillespie
Jun 21, 2015·Fungal Genetics and Biology : FG & B·Gero Steinberg
Nov 1, 2018·Biophysics Reviews·Thomas D Pollard
May 8, 2015·Journal of Microbiology & Biology Education·Joel I Cohen

❮ Previous
Next ❯

Methods Mentioned

BETA
electron
fluorescence microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.