No relationship between plasma desacyl-ghrelin levels and rabeprazole-related delay in gastric emptying : controlled study in healthy volunteers

Drugs in R&D
Takatsugu YamamotoYasushi Kuyama

Abstract

Recent studies have indicated that rabeprazole, a proton pump inhibitor, delays gastric emptying. However, the mechanism of action remains unclear. We conducted this study to clarify whether desacyl-ghrelin (the inactive form of the endogenous growth hormone secretagogue receptor ghrelin) is involved in rabeprazole-induced changes in gastric motor function. Twelve healthy males underwent (13)C-acetate breath tests to evaluate gastric emptying of a liquid meal twice after administration of rabeprazole 20 mg/day for 3 days or no medication (control). Gastric emptying was evaluated by two parameters: half-emptying time and time to peak (13)CO(2) excretion. Plasma desacyl-ghrelin levels were measured in blood samples collected at three time points: immediately pre-test and 1 and 2 hours after ingestion of the test meal. Rabeprazole significantly delayed gastric emptying of the liquid meal. However, plasma desacyl-ghrelin levels after ingestion of the liquid meal showed little difference before or after rabeprazole administration. The results indicate that desacyl-ghrelin was not associated with changes in gastric emptying caused by rabeprazole.

References

Sep 27, 2005·The American Journal of Gastroenterology·Nicholas J TalleyUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Sep 21, 2006·Journal of Gastroenterology and Hepatology·Yoshiko TakahashiYoshikazu Kinoshita
Apr 24, 2007·Journal of Clinical Gastroenterology·Ken-Ichi TakamoriShigeru Kohno
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Masaki SanakaYasushi Kuyama

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Citations

Apr 15, 2011·BMC Gastroenterology·Fritz FrancoisMartin J Blaser
Dec 17, 2009·Digestive Diseases and Sciences·Masaki SanakaYasushi Kuyama
Dec 5, 2012·Expert Opinion on Therapeutic Patents·Hao LiYong-Qing Wang

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