No response of pigeon liver to dimethylnitrosamine acute effects

Cancer Letters
M I Díaz GómezJ A Castro

Abstract

No evidence for liver necrosis was observed at 24, 48 or 72 h after injection of dimethylnitrosamine (DMN) (70 mg/kg, i.p.) to pigeons. The assessment of possible liver necrosis was made by determination of isocitric dehydrogenase (ICD), glutamate oxalacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) in plasma. The ability of pigeon liver slices to metabolize CO2 or to give covalent binding of reactive metabolites to nucleic acids was 24 times smaller than that for rat. Similarly, the pigeon liver microsomes or 9000 X g supernatant have DMN-demethylase activity or ability to activate DMN to reactive metabolites that bind covalently to proteins very close to zero. Results suggest that resistance of pigeon liver to DMN acute effects is related to its lack of ability for DMN metabolic activation.

References

Jan 1, 1976·Mutation Research·R Montesano, H Bartsch
Mar 1, 1975·Toxicology and Applied Pharmacology·R C Shank
Jan 1, 1981·International Journal of Cancer. Journal International Du Cancer·P Bogovski, S Bogovski
Mar 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·M A WALDORFA E HARPER

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Citations

Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·O A de PerezJ A Castro
Jan 1, 1988·Journal of Toxicology and Environmental Health·P E MartinoJ A Castro

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