No serological evidence for Zika virus infection and low specificity for anti-Zika virus ELISA in malaria positive individuals among pregnant women from Madagascar in 2010

PloS One
Norbert G SchwarzJonas Schmidt-Chanasit

Abstract

It was previously reported that a malaria infection may interfere with the specificity of a commercial ELISA test against Zika virus (ZIKV). We analyzed 1,216 plasma samples from healthy, pregnant women collected in two sites in Madagascar in 2010 for ZIKV antibodies using a commercial ELISA and for Plasmodium infection by PCR. This screen revealed six putative ZIKV-positive samples by ELISA. These results could not be confirmed by indirect immunofluorescence assays or virus neutralization tests. Four of these six samples were also positive for P. falciparum. We noted that the frequency of malaria positivity was higher in ZIKV-ELISA positive samples (50% and 100% in the two study sites) than ZIKV-negative samples (17% and 10%, respectively), suggesting that malaria may have led to false ZIKV-ELISA positives.

References

Jan 1, 1978·American Journal of Epidemiology·W J Rogan, B Gladen
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Jul 5, 2008·Emerging Infectious Diseases·Mahery RatsitorahinaJean Louis Soares
Jun 12, 2009·The New England Journal of Medicine·Mark R DuffyEdward B Hayes
Sep 4, 2009·Medical Microbiology and Immunology·Dennis TappeAugust Stich
Oct 1, 2009·Emerging Infectious Diseases·Edward B Hayes
Jul 22, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Dennis TappeAugust Stich
Mar 6, 2012·PLoS Neglected Tropical Diseases·Andrew D HaddowScott C Weaver
Oct 25, 2012·Emerging Infectious Diseases·Norbert G SchwarzRaphael Rakotozandrindrainy
Jun 10, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D MussoV-M Cao-Lormeau
Sep 25, 2015·Emerging Infectious Diseases·Gubio S CamposSilvia I Sardi
Oct 21, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Maite AubryDidier Musso
Mar 5, 2016·The New England Journal of Medicine·Patrícia BrasilKarin Nielsen-Saines
Mar 26, 2016·Science·Nuno Rodrigues FariaPedro F C Vasconcelos
Apr 14, 2016·The New England Journal of Medicine·Sonja A RasmussenLyle R Petersen
Apr 20, 2016·ELife·Jane P MessinaSimon I Hay
Apr 30, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Daniela HuzlyMarcus Panning
Jun 3, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Marjan Van EsbroeckDorien Van den Bossche
Jun 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Lalita PriyamvadaJens Wrammert

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Citations

Jul 11, 2018·The American Journal of Tropical Medicine and Hygiene·Alexandra C WillcoxSteven R Meshnick
Apr 16, 2021·Journal of Clinical Microbiology·Laura C SteinhardtRosemary Audu

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Methods Mentioned

BETA
PCR
ELISAs
ELISA

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