PMID: 11323389Apr 27, 2001Paper

No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer

Carcinogenesis
Amanda B SpurdleG Chenevix-Trench

Abstract

Epidemiological studies suggest that ovarian cancer is an endocrine-related tumour, and progesterone exposure specifically may decrease the risk of ovarian cancer. To assess whether the progesterone receptor (PR) exon 4 valine to leucine amino acid variant is associated with specific tumour characteristics or with overall risk of ovarian cancer, we examined 551 cases of epithelial ovarian cancer and 298 unaffected controls for the underlying G-->T nucleotide substitution polymorphism. Stratification of the ovarian cancer cases according to tumour behaviour (low malignant potential or invasive), histology, grade or stage failed to reveal any heterogeneity with respect to the genotype defined by the PR exon 4 polymorphism. Furthermore, the genotype distribution did not differ significantly between ovarian cancer cases and unaffected controls. Compared with the GG genotype, the age-adjusted odds ratio (95% confidence interval) for risk of ovarian cancer was 0.78 (0.57-1.08) for the GT genotype, and 1.39 (0.47-4.14) for the TT genotype. In conclusion, the PR exon 4 codon 660 leucine variant encoded by the T allele does not appear to be associated with ovarian tumour behaviour, histology, stage or grade. This variant is also not ass...Continue Reading

Citations

Feb 19, 2005·American Journal of Epidemiology·Kathryn L TerryDaniel W Cramer
Jan 6, 2005·Journal of the National Cancer Institute·Celeste Leigh PearceMalcolm C Pike
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M G JunqueiraW J Gonçalves
Nov 8, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ting LiuWen Di
Apr 4, 2008·Steroids·Daniela B LeiteIsmael D C G da Silva
Dec 22, 2006·Cancer Letters·Christina M NagleAmanda B Spurdle
Sep 18, 2014·The Journal of Obstetrics and Gynaecology Research·Jing LiaoDing Ma
Sep 17, 2015·Endocrine-related Cancer·Helen GharwanChristina M Annunziata
Nov 22, 2005·Molecular and Cellular Endocrinology·Jean S FlemingOlivia L Tan
Jun 7, 2011·Biochimica Et Biophysica Acta·M G M BraemN C Onland-Moret
Nov 5, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·Paul D P Pharoah, Bruce A J Ponder
Mar 20, 2001·Molecular Carcinogenesis·A B SpurdleG Chenevix-Trench
Aug 30, 2005·Molecular Human Reproduction·Susan A TreloarGrant W Montgomery
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Karen A PooleyAlison M Dunning
Apr 6, 2007·Cancer Research·Simon A GaytherUNKNOWN Ovarian Cancer Association Consortium
Nov 19, 2004·Cancer Research·Sherri L StewartChristos Patriotis

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