Abstract
The excess cardiac risk, found in RA has been attributed to biological inflammation. Effective control of inflammation may be of benefit in reducing cardiovascular risk in RA patients. The aim of this study is to investigate the effects of 24 and 52 weeks of rituximab treatment on arterial stiffness and cardiovascular risk factors. Arterial stiffness was measured by augmentation index (AIx) and pulse wave velocity (PWV), and other cardiovascular risk factors (lipid profile, blood pressure) were collected in active RA patients. Thirty-three patients, of whom 29 were females, with a mean age of 60.9 (12.0) years were included. Thirty patients had positive RFs, 27 had positive anti-CCP antibody and 93.9% (n = 31) were erosive. Nineteen patients were non-responders to anti-TNF-α treatments. After rituximab treatment, no change was observed in arterial stiffness, neither after 6 nor after 12 months [PWV 8.1 (3.1) m/s at baseline, 8.1 (2.8) at 6 months, 8.0 (2.7) at 1 year, P = 0.924; and AIx 30.4 (8.2)% at baseline, 28.6 (7.6) at 6 months, 29.4 (6.7) at 1 year, P = 0.216]. Total and low-density lipoprotein cholesterol levels increased significantly but high-density lipoprotein (HDL) and triglyceride levels were unchanged. The athero...Continue Reading
References
Jan 16, 2003·Arthritis and Rheumatism·Melinda WongAlicia Jenkins
Dec 17, 2003·Circulation·Naveed SattarIain B McInnes
Apr 14, 2004·Circulation·Subodh VermaMichael J B Kutryk
Dec 4, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Göran WalldiusAllan D Sniderman
Aug 4, 2005·Rheumatology·S Van DoornumI P Wicks
Sep 2, 2006·Arthritis and Rheumatism·Stanley B CohenUNKNOWN REFLEX Trial Group
Sep 6, 2006·Circulation·Kaisa M Mäki-PetäjäIan B Wilkinson
Sep 30, 2008·Arthritis and Rheumatism·Shouvik DassPaul Emery
Nov 28, 2008·Arthritis and Rheumatism·Carlos Gonzalez-JuanateyMiguel A Gonzalez-Gay
Nov 28, 2008·Arthritis and Rheumatism·J Antonio Aviña-ZubietaDiane Lacaille
Jan 20, 2009·Current Pharmaceutical Design·Kaisa M Mäki-Petäjä, Ian B Wilkinson
Mar 26, 2009·Clinical Rheumatology·György KerekesZoltán Szekanecz
Aug 22, 2009·Rheumatology·Christophe MeuneYannick Allanore
May 7, 2010·Annals of the Rheumatic Diseases·Daniel H SolomonJeffrey D Greenberg
Jul 7, 2010·The Journal of Experimental Medicine·Hafid Ait-OufellaZiad Mallat
Oct 20, 2010·Arthritis Care & Research·Cheryl BarnabeWilliam A Ghali
Aug 24, 2011·Hypertension·Bas C van BusselCoen D Stehouwer
Citations
Aug 30, 2014·BioMed Research International·Miodrag JanićMišo Sabovič
Oct 16, 2014·Current Rheumatology Reports·Debbie T LimTed R Mikuls
Dec 22, 2012·Expert Review of Clinical Immunology·Claudio Ponticelli
Dec 7, 2013·Expert Review of Clinical Immunology·Samuel Morris-RosenfeldColeen A McNamara
Jan 28, 2014·Annals of Medicine·Matteo Nicola Dario Di MinnoUNKNOWN CaRRDs Study Group
Jun 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Jiayun ShenLai-Shan Tam
Feb 24, 2016·Vascular Pharmacology·Gerhard W NaerrHeinz Drexel
Jun 2, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Martin SoubrierSylvain Mathieu
Sep 25, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine QuinlanKjell Tullus
Sep 20, 2012·Mediators of Inflammation·Calin D PopaPiet L C M van Riel
Oct 16, 2013·Atherosclerosis·D F van Breukelen-van der StoepM Castro Cabezas
Jun 15, 2014·Clinical Rheumatology·Dimitrios VassilopoulosChristodoulos Stefanadis
Jun 27, 2015·PloS One·Sella Aarrestad ProvanAnne Grete Semb
Aug 20, 2016·Expert Review of Cardiovascular Therapy·Martin GersterValentina O Puntmann
Oct 5, 2016·Annals of the Rheumatic Diseases·R AgcaM T Nurmohamed
Jan 11, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Michael NurmohamedPaola Accossato
Oct 11, 2016·Therapeutic Advances in Musculoskeletal Disease·Anne TournadreMartin Soubrier
Jul 19, 2014·World Journal of Orthopedics·Antongiulio ScarnoAntonio Spadaro
Feb 4, 2016·Journal of Korean Medical Science·Diana S NovikovaEvgeny L Nasonov
Jun 12, 2020·Rheumatology International·Aliki I VenetsanopoulouAlexandros A Drosos
Mar 28, 2017·Clinical Rheumatology·Chun LiZ G Li
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Elena BartoloniRoberto Gerli
Dec 19, 2019·Rheumatology International·Edit VéghGabriella Szűcs
Jul 28, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Charlotte GiraudAnne Tournadre
Dec 18, 2020·International Journal of Molecular Sciences·Tapan BehlSimona Bungau
Mar 7, 2021·Expert Review of Clinical Immunology·George A KarpouzasSarah R Ormseth
Apr 10, 2021·Nature Reviews. Rheumatology·Fabiola AtzeniZoltán Szekanecz
Jul 7, 2021·Autoimmunity Reviews·Marie BergerCamille Roubille