No significant change of plasma beta-endorphin levels of psoriasis patients after synchronous balneophototherapy

Photodermatology, Photoimmunology & Photomedicine
P HollóA Horváth

Abstract

Previous studies suggested that beta-endorphin has a pathogenic role in psoriasis: its increased plasma concentration may play a role in the neuroimmunological processes in the pathomechanism of the disease, and plasma beta-endorphin levels should reflect the changes in the patients' skin status. The purpose of this study was to investigate the changes of peripheral blood beta-endorphin levels in psoriatic patients in conjunction with changes in their skin symptoms after synchronous balneophototherapy. With synchronous balneophototherapy, 12 patients with extended skin symptoms of psoriasis were treated. The therapy followed the Regensburg protocol, consisting of a basic course of 35 sessions. Patients' skin status was characterized by evaluating the Psoriasis Area and Severity Index score before and after the therapy course. Blood samples were taken before treatment, and 1 day after the last session, with symptom-free skin. Plasma beta-endorphin levels were measured by a specific radioimmunoassay developed by the authors. There was no significant change in plasma levels of beta-endorphin after clinical clearance of psoriatic skin symptoms. In this non-randomized, uncontrolled study no significant difference could be detected b...Continue Reading

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Citations

May 8, 2007·European Journal of Applied Physiology·Tamás BenderPál Géher
May 17, 2013·International Journal of Biometeorology·T BenderI K Tefner
Aug 30, 2008·Clinics in Dermatology·Jana KazandjievaNikolai Tsankov
May 6, 2020·The Cochrane Database of Systematic Reviews·Frank PeinemannThilo Gambichler

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