No Significant Effects of IL-6 and IL-13 Gene Variants on Tuberculosis Susceptibility in the Chinese Population

DNA and Cell Biology
Wei SunBinwu Ying

Abstract

Tuberculosis (TB) is an intricate infectious disease that causes a large number of deaths in the population. Interleukin (IL)-6 and IL-13 play functional roles in host resistance to Mycobacterium tuberculosis infection. Our aim in this study was to explore the association of IL-6 and IL-13 polymorphisms with TB susceptibility in the Western Chinese Han population. The case and control groups comprised 900 TB patients and 1534 healthy controls, respectively, and four single-nucleotide polymorphisms (SNPs) were genotyped in IL-6 and five SNPs in IL-13 through the improved multiplex ligation detection reaction method. We found no genetic variants in the IL-6 or IL-13 genes that were related to TB susceptibility in the analysis of alleles, genotypes, genetic models, and TB clinical subtypes, except for a trend toward low pulmonary tuberculosis and extrapulmonary tuberculosis susceptibility for the SNPs rs1295686 and rs20541. Our study did not find a link between IL-6 and IL-13 polymorphisms and TB susceptibility in the Western Chinese Han population. Therefore, our present data revealed the challenge of applying IL-6 and IL-13 SNPs as genetic markers for TB and that increased sample sizes and additional races are needed for further...Continue Reading

References

Nov 13, 2004·The Journal of Allergy and Clinical Immunology·Erwin W Gelfand
May 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kazuya MasudaTadamitsu Kishimoto
Jun 8, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·A NolanM D Weiden
Jun 27, 2013·Journal of Medical Primatology·Morteza RoodgarDavid Glenn Smith
Sep 13, 2013·Current Allergy and Asthma Reports·Jonathan Corren
Jul 1, 2014·The Journal of Pathology·Lisa HeitmannChristoph Hölscher
Dec 19, 2014·Genes and Immunity·Noémi Borsay HallUNKNOWN Tuberculosis Research Unit (TBRU)
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Sep 18, 2015·Lancet·Keertan DhedaGary Maartens
Oct 18, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chao ZhouQing Liu
Feb 2, 2016·Nature Genetics·Gardar SveinbjornssonKari Stefansson
May 14, 2016·Journal of Periodontal Research·S B FarhatP C Trevilatto
Feb 23, 2017·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·R KamakiaJ Oyugi
May 4, 2017·American Journal of Respiratory and Critical Care Medicine·Javeed A ShahThomas R Hawn
May 2, 2018·Scientific Reports·Sugata RoyHarukazu Suzuki
Jul 30, 2019·International Journal of Endocrinology·Angélica Saraí Jiménez-OsorioMartha Eunice Rodríguez-Arellano
Nov 11, 2019·The Lancet. Respiratory Medicine·Emilia Harding
Nov 14, 2019·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Eva L SudburyNigel Curtis
Nov 26, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yukari C ManabeAmita Gupta
Dec 16, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jingwei ZhangBinwu Ying

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Citations

Dec 19, 2020·Cells·Kristina RitterChristoph Hölscher

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Methods Mentioned

BETA
Genotyping

Software Mentioned

Haploview
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