No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19

Nanomedicine
Georgia Wilson JonesBengt Fadeel

Abstract

There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.

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Citations

Jan 6, 2021·Computational and Structural Biotechnology Journal·Muhammad Fayyaz Ur RehmanMuhammad Farhan Ul Haque
Feb 9, 2021·Emergent Materials·Abhimanyu TharayilNandakumar Kalarikkal
Feb 28, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fernanda PilaquingaMaría de Las Nieves Piña
Feb 23, 2021·Emergent Materials·Farzan Vahedifard, Krishnan Chakravarthy
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Jun 1, 2021·Medicine in Drug Discovery·Tahereh Seifi, Ali Reza Kamali
Jun 22, 2021·Journal of Molecular Structure·Tean ZaheerMaría Del Pilar Rodríguez Torres

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Methods Mentioned

BETA
bronchoalveolar lavage
glycosylation
affinity purification

Software Mentioned

SOLIDARITY

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