No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19

Georgia Wilson JonesBengt Fadeel


There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.


Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A JeffersKathryn V Holmes
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Jan 28, 2006·The Lancet Infectious Diseases·Andrea SavarinoAntonio Cassone
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Anna A ShvedovaBengt Fadeel
Apr 2, 2010·Journal of the American Chemical Society·Dorota WalczykKenneth A Dawson
Sep 7, 2012·Angewandte Chemie·Carlo FastingRainer Haag
Dec 6, 2012·Nature Nanotechnology·Marco P MonopoliKenneth A Dawson
Apr 16, 2013·Nature Nanotechnology·Che-Ming J HuLiangfang Zhang
Sep 17, 2015·Nature·Che-Ming J HuLiangfang Zhang
Jan 31, 2016·Advanced Drug Delivery Reviews·Vaishali BagalkotAndrei Maiseyeu
Mar 26, 2016·ACS Applied Materials & Interfaces·Alexandre BarrasSabine Szunerits
Oct 12, 2017·Environmental Health Perspectives·Vicki StoneFlemming R Cassee
Oct 24, 2017·Lancet·Philip J LandriganMa Zhong
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Soracha ThamphiwatanaLiangfang Zhang
Dec 19, 2017·Nature Materials·Valeria CagnoFrancesco Stellacci
Jun 20, 2018·Nature Nanotechnology·Manuel TonigoldVolker Mailänder
Jul 8, 2018·Nature Nanotechnology·Bengt FadeelKai Savolainen
Sep 27, 2018·Advanced Materials·Xiaoli WeiLiangfang Zhang
Oct 13, 2018·Nature Reviews. Drug Discovery·Sudeep PushpakomMunir Pirmohamed
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Jan 22, 2019·Nanoscale·Alberto BerardiGeorge P Lomonossoff
May 28, 2019·Nature Communications·Kariem EzzatSamir El Andaloussi
Oct 22, 2019·ACS Applied Materials & Interfaces·Aleksandra ŁoczechinSabine Szunerits
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 5, 2020·Nature Reviews. Drug Discovery·Guangdi Li, Erik De Clercq

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Methods Mentioned

bronchoalveolar lavage
affinity purification

Software Mentioned


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Antivirals (ASM)

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