No strong evidence for increased risk of breast cancer 8-26 years after multiple mammograms in their 30s in females at moderate and high familial risk

The British Journal of Radiology
D Gareth EvansA Howell

Abstract

To assess the risks of induction of breast tumours from frequent screening mammography in younger females. A study group of 853 females was identified who had at least 5 mammograms starting before 37 years of age, with 4 or more before the age of 40 years. These were followed up from their 40th birthday or 8 years from their first mammogram, and their cancer incidence was compared with that of a control group of 1103 females who had an average of 5 mammograms between the ages of 40 and 46 years. All females in the study were previously assessed to be at moderate familial risk or higher. There were 43 incident breast cancers in the study group after the 8-year start point, whereas 38.3 were expected from life-table calculations (RR 1.12; 95% CI: 0.83 to 1.51). In the control group, 50 incident breast cancers developed some time after their first mammogram in follow up to age 60 years. The observed, expected ratio from life tables in this group was 0.94 (95% CI: 0.71-1.24), similar to that in the study group. There was no trend to greater cancer incidence in those receiving mammograms earlier. This study shows that there is no substantial effect on the induction of additional primary breast tumours from frequent mammography start...Continue Reading

References

Aug 1, 1977·Annals of Internal Medicine·A B SchneiderL A Frohman
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Mar 30, 2007·CA: a Cancer Journal for Clinicians·Debbie SaslowUNKNOWN American Cancer Society Breast Cancer Advisory Group
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Jun 27, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony J SwerdlowMichael V Williams
Jun 27, 2013·BMJ : British Medical Journal·D Gareth EvansDeborah Fitzsimmons

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