PMID: 9159647Feb 1, 1997Paper

No suppression of respiratory function of mitochondrial isolated from the hearts of anesthetized rats with high-dose pentobarbital sodium

The Japanese Journal of Physiology
M TakakiH Suga

Abstract

Pentobarbital sodium is a widely used anesthetic for animal experiments. We have already reported that a high dose of pentobarbital sodium (100 mg/kg i.p., twice the usual anesthetic dose) depresses myocardial mechanoenergetics in the canine heart. Furthermore, it has been reported that a high concentration of pentobarbital sodium inhibits myocardial contractility and mitochondrial electron transport and energy transfer. Therefore, we were afraid that the mitochondrial respiratory function would be impaired by pentobarbital anesthesia and that pentobarbital sodium would be an inappropriate anesthetic for cardiac mechanoenergetic studies. In this study, we investigated the respiratory function of mitochondria isolated from the hearts of anesthetized rats with high-dose pentobarbital sodium. We examined the mitochondrial respiratory function by the ADP/O ratio, respiratory control index (RCI), oxygen consumption rate in state III (State III O2) by oximetry, and membrane potential using a fluorescent dye, 3,3'-dipropylthiodicarbocyanine iodide (diS-C3-(5). The ADP/O ratio, RCI, and State III O2 values and changes in membrane potential induced by various respiratory substances were not significantly different between the rats with ...Continue Reading

Citations

Jan 30, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Christopher Armstrong, James F Staples
Jan 6, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Dillon ChungJames F Staples
Sep 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Judith A HerleinWilliam I Sivitz
Sep 6, 2008·Endocrinology·Judith A HerleinWilliam I Sivitz
Jan 1, 2012·Journal of Experimental Stroke & Translational Medicine·Shimin Liu, Jiang-Fan Chen
Feb 25, 2014·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Alex N CooperJames F Staples
Jan 11, 2013·Physiological and Biochemical Zoology : PBZ·Kirsten Gallagher, James F Staples
Jan 19, 2010·Biochimica Et Biophysica Acta·Jason C L Brown, James F Staples
Jan 19, 2013·Diabetes·Liping YuWilliam I Sivitz
Aug 9, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Katherine E MathersJames F Staples
May 31, 2018·American Journal of Physiology. Endocrinology and Metabolism·Surendra DasariMatthew M Robinson
Sep 7, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason C L BrownJames F Staples
May 9, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine E Mathers, James F Staples
Dec 6, 2019·Experimental Physiology·Amina EshreifJohn R Ussher
Apr 11, 2013·Physiological Genomics·Dillon J ChungJames F Staples
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Philip James EdwardsSarah Pratap
Jan 13, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah V McFarlaneJames F Staples
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Takehisa AbeMiyako Takaki
Apr 23, 2021·Free Radical Biology & Medicine·Birgitte S JensenAngela Fago
Aug 12, 2008·The Journal of Experimental Biology·Alexander R GersonJames F Staples
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