No Time to Delay! Fiebig Stages and Referral in Acute HIV infection: Seattle Primary Infection Program Experience

AIDS Research and Human Retroviruses
Joanne D SteklerAnn C Collier

Abstract

There has been increasing recognition of the importance of diagnosing individuals during the earliest stages of human immunodeficiency virus (HIV) infection. Sera from individuals referred to a primary HIV infection research program were screened using the IgG-sensitive Vironostika HIV-1 Microelisa System, IgG/IgM-sensitive GS HIV-1/HIV-2 Plus O antibody enzyme immunoassay (EIA), or Abbott ARCHITECT HIV antigen (Ag)/antibody (Ab) Combo assay and confirmed by the Bio-Rad Multispot and Western blot. A subset of participants was co-enrolled in a study designed to compare the ability of point-of-care tests to detect early infection. We calculated time within primary infection laboratory stages using actual observed transitions and with an expectation-maximization algorithm. Three hundred and sixty participants contributed data to this analysis. Of 123 persons referred with EIA-negative/RNA-positive test results (Fiebig stage I-II) or for concern for symptoms, 24 (20%) were still in stages I-II, and 99 (80%) were in stages III or later at their screening visit. Participants were estimated to spend a median of 13.5 days in stages I and II, 2.3 days in stage III, and 7.8 days in stage IV. OraQuick performed on oral fluids detected 53%...Continue Reading

References

Aug 15, 1996·Annals of Internal Medicine·T SchackerL Corey
Dec 16, 1998·Annals of Internal Medicine·T W SchackerL Corey
Jul 5, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bhupat D RawalMichael P Busch
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Denise KotheJoanne V Mei
May 6, 2005·The New England Journal of Medicine·Christopher D PilcherPeter A Leone
Aug 12, 2005·The New England Journal of Medicine·Jeffrey D KlausnerCharlotte K Kent
Feb 22, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Frances H PriddyCarlos del Rio
Jun 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joanne D SteklerMatthew R Golden
Jul 19, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Alessandra AmendolaMaria Rosaria Capobianchi
Oct 11, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Silvina MasciotraS Michele Owen
Dec 31, 2011·The Journal of Infectious Diseases·Nora E RosenbergWilliam C Miller
Jan 18, 2013·The New England Journal of Medicine·Tuan LeSunil K Ahuja
Dec 18, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Joanne D SteklerBernard M Branson
Jun 17, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ilesh V JaniTrevor F Peter
Apr 24, 2015·Antiviral Therapy·Janine MaenzaAnn C Collier
Jan 18, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Joanne D SteklerMatthew R Golden
May 19, 2016·The New England Journal of Medicine·Merlin L RobbUNKNOWN RV 217 Study Team
Jun 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark S de SouzaUNKNOWN RV254/SEARCH010 Study Group
Jul 20, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christopher D PilcherHiroyu Hatano
Nov 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kevin P DelaneySherry Michele Owen
Apr 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcel E CurlinUNKNOWN OraQuick Study Group
Jul 12, 2017·AIDS·Deborah DonnellUNKNOWN Partners PrEP Study Team

❮ Previous
Next ❯

Citations

May 30, 2020·Acta Clinica Belgica·Jozefien De ClercqLinos Vandekerckhove
Jan 30, 2021·Open Forum Infectious Diseases·Karina OganezovaLindsey R Baden
Jan 1, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Trevor A CrowellUNKNOWN AIDS Clinical Trials Group A5354/EARLIER (Early ART to Limit Infection and Establishment of Reservoir) Study Team
Jun 19, 2021·Scientific Reports·Miłosz ParczewskiPiotr Grabarczyk

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleic acid amplification
enzyme-linked immunosorbent assay

Software Mentioned

Uni
INSTI
R
OraQuick
Stata SE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Lucia V TorianWilliam R Oleszko
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Ana María CárdenasRichard L Hodinka
© 2022 Meta ULC. All rights reserved