PMID: 711624Sep 1, 1978Paper

Noboritomycins A and B, new polyether antibiotics

The Journal of Antibiotics
C Keller-JuslénA von Wartburg

Abstract

Noboritomycins A and B, two new polycyclic ionophoric polyethers were isolated from a strain of Streptomyces noboritoensis. The crystal structure and absolute configuration of noboritomycin A were established by X-ray analysis of its silver salt C43/63O14Ag. Noboritomycin A is the first metabolic polyether possessing two carboxylic acid functions on the carbon backbone (C-31), namely a free acid and an additional carboxylic acid ethylester group. An unusual spiroketal system as well as a salicylic acid chromophore represent further remarkable elements. Noboritomycin A shows in this respect a structural relationship to salinomycin and lasalocid respectively. Comparison of physico-chemical data, in particular the interpretation of the 1H- and 13C-NMR spectra, revealed that noboritomycins A and B are structurally closely related, noboritomycin B carrying an ethyl substituent on the aromatic ring in the place of a methyl group present in noboritomycin A. Both metabolites exhibit activity against Gram-positive bacteria and against Eimeria tenella (chicken coccidiosis).

Citations

Apr 16, 2013·BioMed Research International·Jacek Rutkowski, Bogumil Brzezinski

Related Concepts

Antibiotics
Ethers
Fermentation
Ionophores
Fungus Drug Sensitivity Tests
In Vivo NMR Spectroscopy
Streptomyces

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