Nocardia infections in solid organ transplantation: Guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation

Clinical Transplantation
Alejandro RestrepoInfectious Diseases Community of Practice of the American Society of Transplantation

Abstract

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of Nocardia infections after solid organ transplantation (SOT). Nocardia infections have increased in the last two decades, likely due to improved detection and identification methods and an expanding immunocompromised population. The risk of developing nocardiosis after transplantation varies with the type of organ transplanted and the immunosuppression regimen used. Nocardia infection most commonly involves the lung. Disseminated infection can occur, with spread to the bloodstream, skin, or central nervous system. Early recognition of the infection and initial appropriate treatment is important to achieve good outcomes. Species identification and antimicrobial susceptibility testing are strongly recommended, as inter- and intraspecies susceptibility patterns can vary. Sulfonamide is the first-line treatment of Nocardia infections, and combination therapy with at least two antimicrobial agents should be used initially for disseminated or severe nocardiosis. Trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis may be helpful in preventing Nocardia infection after ...Continue Reading

References

Mar 1, 1978·Radiology·J P BalikianS Kopit
Feb 1, 1979·Archives of Internal Medicine·M V WrenR H Alford
Aug 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P BoironB Dupont
Dec 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F GarlandoM Pirovino
Sep 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M M McNeilZ M Blacklock
Jun 1, 1991·The Journal of Hospital Infection·M SahathevanM W Casewell
Nov 11, 1991·Journal of Clinical Microbiology·R J WallaceG O Onyi
Jan 1, 1991·Reviews of Infectious Diseases·J E Bross, G Gordon
Jul 1, 1989·The Journal of Antimicrobial Chemotherapy·M E GombertL B Berkowitz
Dec 1, 1988·Antimicrobial Agents and Chemotherapy·R J WallaceJ M Smith
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·P BerkeyK Rolston
Nov 1, 1988·The Journal of Antimicrobial Chemotherapy·P Boiron, F Provost
Mar 1, 1988·Diagnostic Microbiology and Infectious Disease·R J Wallace, L C Steele
Oct 1, 1987·Journal of Clinical Microbiology·P R MurrayA C Niles
Apr 1, 1983·Archives of Internal Medicine·R A SmegoH A Gallis
Nov 1, 1983·Antimicrobial Agents and Chemotherapy·M E Gombert, T M Aulicino
Mar 1, 1982·Reviews of Infectious Diseases·R J WallaceD C Hollowell
Jan 1, 1982·Infection and Immunity·B L BeamanR Deem
May 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N M ClarkC E Chenoweth
Jul 1, 1994·Clinical Microbiology Reviews·M M McNeil, J M Brown
Mar 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R B UttamchandaniM R Kramer
Apr 1, 1994·Clinical Microbiology Reviews·B L Beaman, L Beaman
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·V A SteingrubeD R Nash
Feb 1, 1993·Southern Medical Journal·C T KingD E Butkus
Apr 1, 1993·Antimicrobial Agents and Chemotherapy·N KhardoriK Rolston
Apr 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R C ArduinoA G Miranda
Apr 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J E Gallant, A H Ko
Apr 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N VelascoA F Rahman
Jun 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P I Lerner
Nov 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C ChouciñoJ S Dummer
May 6, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·D MerigouC Beylot
Jun 12, 1998·The New England Journal of Medicine·J A Fishman, R H Rubin
Oct 21, 1998·The Journal of Infectious Diseases·P N WengerW R Jarvis
Aug 12, 2000·International Journal of Systematic and Evolutionary Microbiology·A F YassinK P Schaal

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Citations

Jul 4, 2020·Current Opinion in Organ Transplantation·Jennifer L Saullo, Rachel A Miller
Oct 10, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Caroline MatchettSandesh Parajuli
Sep 2, 2020·Scientific Reports·Ili MargalitKhitam Muhsen
Apr 8, 2020·Open Forum Infectious Diseases·Natalie DavidsonNicholas M Anstey
Jun 23, 2019·Current Infectious Disease Reports·Marion Hemmersbach-MillerJennifer L Saullo
Sep 30, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Kellie J GoodletMichael D Nailor
Oct 28, 2020·Expert Review of Respiratory Medicine·Lorena van den BogaartOriol Manuel
Oct 21, 2020·Antimicrobial Agents and Chemotherapy·Ka Lip ChewJeanette W P Teo
Jan 9, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Ili MargalitJulien Coussement
Dec 31, 2020·Infection and Drug Resistance·Emmanuel LafontDavid Lebeaux
Jun 13, 2020·Respiratory Medicine Case Reports·Lea DeterdingHans-Jürgen Seyfarth
Mar 21, 2021·Current Opinion in Infectious Diseases·Nitin das Kunnathu Puthanveedu, Jessica Lum
Jun 19, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Pierre-Louis ConanDavid Lebeaux
Aug 5, 2021·European Journal of Medical Research·Jiangqin SongJunyang Zhou
Aug 28, 2021·World Journal of Clinical Cases·Ping WangCheng-Zhou Zhang
Dec 29, 2020·Transplantation Proceedings·Matan UrielTakeo Fujino
May 19, 2020·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Shalini Dewan Duggal, Tulsi Das Chugh
Nov 2, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Zachary A YetmarElena Beam

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