Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. I. Taxonomy, fermentation and biological activities

The Journal of Antibiotics
Wenying LiKin S Lam

Abstract

Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml) against a wide spectrum of gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.

Citations

Apr 5, 2005·Natural Product Reports·Zhong Jin
Feb 5, 2005·Natural Product Reports·Masanori Somei, Fumio Yamada
Feb 11, 2009·Biotechnology Progress·Beth JunkerNeal Connors
Aug 9, 2011·Expert Review of Anti-infective Therapy·Sheo B SinghLynn Miesel
Dec 7, 2017·Frontiers in Pharmacology·Shivankar AgrawalSunil K Deshmukh
Jan 31, 2020·Frontiers in Chemistry·Kunlong LiHuaming Tao
Feb 5, 2005·Natural Product Reports·John W BluntMichele R Prinsep
Jul 27, 2010·Expert Opinion on Therapeutic Patents·Sheo B Singh, Katherine Young
Aug 29, 2013·Environmental Microbiology·Quan LuoAlexander Steinbüchel
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Kun FengYijun Chen
Oct 18, 2014·Amino Acids·Dawid Siodłak
Sep 19, 2014·Perspectives in Medicinal Chemistry·Richard J Fair, Yitzhak Tor
Jun 3, 2014·Natural Product Reports·Yousef DashtiRonald J Quinn
Nov 4, 2015·Current Protocols in Microbiology·Dipesh Dhakal, Jae Kyung Sohng
Mar 29, 2007·Natural Product Reports·Brent R Copp, A Norrie Pearce
Aug 19, 2017·Natural Product Reports·Olga Genilloud
Sep 11, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jiaqi LuanMengxiang Su
Jan 20, 2019·Journal of Industrial Microbiology & Biotechnology·Dipesh DhakalJae Kyung Sohng
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jun IshikawaMasahira Hattori
Jul 28, 2012·Antonie van Leeuwenhoek·Tomohiko TamuraNobuyuki Fujita
Nov 29, 2015·Chinese Journal of Natural Medicines·Lei JiangYi-Jun Chen
Oct 10, 2009·Organic Letters·Fredrik LehmannMartin Scobie
Feb 11, 2005·Chemical Reviews·Mark C BagleyXin Xiong
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Michael J PucciYasutsugu Ueda
Apr 2, 2009·Journal of Natural Products·Chaowei ZhangSheo B Singh
Jun 29, 2021·Tetrahedron Letters·Eric D Huseman, Steven D Townsend
Mar 4, 2017·Chemical Reviews·Brandon J BurkhartDouglas A Mitchell
Apr 4, 2015·The Journal of Organic Chemistry·Hee-Jong Hwang, Marco A Ciufolini
Jan 13, 2015·ACS Chemical Biology·Feifei Zhang, Wendy L Kelly
Apr 10, 2012·Journal of Natural Products·Thomas P WycheTim S Bugni
Nov 13, 2018·Journal of the American Chemical Society·Patricia AmaraYvain Nicolet
Jun 4, 2019·Chemical Reviews·Ivan V SmolyarValentine G Nenajdenko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
John DotisEmmanuel Roilides
Antimicrobial Agents and Chemotherapy
Carmen BetriuSpanish Group of Tigecycline
© 2022 Meta ULC. All rights reserved