Nociceptin and the nociceptin receptor in learning and memory

Progress in Neuro-psychopharmacology & Biological Psychiatry
Raül Andero

Abstract

There are many processes in which the neuropeptide nociceptin/orphanin FQ (N/OFQ or nociceptin) is involved in the brain. The role of nociceptin in learning and memory holds promise in modulating these processes in health and disease in the human brain. This review summarizes the body of research focused on N/OFQ and its specific receptor, the nociceptin receptor (NOP receptor), in learning and memory, and its potential mechanisms of action, in which acetylcholine, NMDA receptor, and noradrenaline may be critical. Finally, the association between NOP receptor and posttraumatic stress disorder (PTSD), a psychiatric disorder with altered fear learning, is examined as one of the potential outcomes resulting from pathological consequences of dysregulation of N/OFQ-NOP receptor in the brain.

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Citations

Jul 16, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Takehito SawamuraRaül Andero
Apr 26, 2016·Experimental Neurology·Lauren A M LeboisKerry J Ressler
May 31, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Raül AnderoKerry J Ressler
Jul 25, 2019·Journal of Psychopharmacology·Victor A D HolandaChiara Ruzza
Jan 8, 2020·The American Journal of Psychiatry·Daniel F LeveyMurray B Stein
Sep 27, 2018·Psychopharmacology·Travis D Goode, Stephen Maren

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