Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect

Physiology & Behavior
Roberto CiccocioppoMaurizio Massi

Abstract

Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP opioid receptor (previously referred to as ORL1 or OP4 receptor), exerts a variety of behavioral effects. N/OFQ as well as the synthetic NOP receptor agonist Ro 64-6198 have been reported to possess antistress properties and to elicit a pronounced hyperphagic effect in freely feeding rats. These findings have raised our interest to investigate possible interactions in the control of ingestive behavior between N/OFQ and corticotropin-releasing factor (CRF), which is well known to be a major mediator of stress and to possess anorectic properties. These studies have shown that intracerebroventricular injections of N/OFQ or of Ro 64-6198 reverse the anorectic action evoked by intracerebroventricular administration of CRF. The anti-anorectic effect of N/OFQ or Ro 64-6198 is antagonized by the selective NOP receptor antagonist [Nphe1]N/OFQ1-13NH2, providing evidence that it is mediated by this receptor. The effect occurs at doses that are not hyperphagic per se and is clearly selective versus the anorectic action of CRF since N/OFQ or Ro 64-6198 do not influence the anorectic effect of Escherichia coli lipopolysaccharide (LPS). Neither N/OFQ nor Ro 64-6198 shows affinit...Continue Reading

References

Jan 27, 1977·The New England Journal of Medicine·R M BoyarD K Fukushima
Nov 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·I SchweitzerB M Davies
Jan 1, 1989·Archives of General Psychiatry·H E GwirtsmanP W Gold
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W LovenbergT Oltersdorf
Apr 16, 1996·Psychiatry Research·J LicinioP W Gold
Dec 31, 1997·Brain Research. Brain Research Reviews·P Y Risold, L W Swanson
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·F JenckO Civelli
Jul 23, 1999·Brain Research·G GriebelD J Sanger
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KösterR K Reinscheid
Apr 1, 2000·British Journal of Pharmacology·G Calo'D Regoli
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·F JenckG Kilpatrick
Sep 22, 2000·Peptides·C PolidoriM Massi
Dec 29, 2000·Molecular Psychiatry·F JenckJ L Moreau
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Dec 26, 2001·Brain Research. Brain Research Reviews·H W DongL W Swanson

❮ Previous
Next ❯

Citations

Feb 24, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Elaine C Gavioli, Girolamo Calo'
Jun 6, 2008·Brain Structure & Function·David L Walker, Michael Davis
Feb 27, 2013·Behavioural Brain Research·Roberto Sebastián Miranda-MoralesNorman E Spear
Apr 30, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pawel K OlszewskiAllen S Levine
Dec 3, 2011·International Journal of Medical Sciences·Tasneem Fatema Hasan, Hunaid Hasan
Nov 6, 2013·Pharmacology & Therapeutics·Jeffrey M WitkinRoberto Ciccocioppo
May 28, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roberto CiccocioppoKoji Teshima
May 10, 2011·Physiology & Behavior·Rebecca L CorwinMary M Boggiano
Jan 14, 2009·Physiology & Behavior·Miwako KoizumiNiall P Murphy
May 26, 2010·CNS Neuroscience & Therapeutics·Girolamo Calo'Remo Guerrini
Oct 14, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S Agostini, C Petrella
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Jun 30, 2005·Life Sciences·Mary M Heinricher
Nov 22, 2011·Neuroscience and Biobehavioral Reviews·Nicholas W Gilpin, Marisa Roberto
Apr 18, 2013·Brain Research Bulletin·Nadezhda Bazhan, Dóra Zelena
Jul 12, 2005·CNS Drug Reviews·Girolamo CaloDomenico Regoli
Dec 6, 2014·Molecules and Cells·Thomas L KashZoe A McElligott
Jul 22, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda C MaracleMary C Olmstead
Feb 26, 2020·Psychopharmacology·Aldemara I SilvaElaine C Gavioli
May 12, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonia SerranoLoren H Parsons
Mar 7, 2021·International Journal of Molecular Sciences·Francesca Felicia CaputiPatrizia Romualdi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.