PMID: 10998536Sep 22, 2000Paper

Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system

Peptides
E Schlicker, Michele Morari

Abstract

In this article, the effect of nociceptin (orphanin FQ) on transmitter release in the central nervous system in vitro and in vivo is reviewed. Nociceptin inhibits the electrically or K(+)-evoked noradrenaline, dopamine, serotonin, and glutamate release in brain slices from guinea-pig, rat, and mouse. This effect is usually naloxone-resistant but antagonized by OP(4) receptor antagonists like [Phe(1)psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2). In the rat in vivo, nociceptin diminishes acetylcholine release in the striatum, reduces dopamine release, and prevents the stimulatory effect of morphine on this transmitter in the nucleus accumbens and also elevates extracellular glutamate and gamma-aminobutyric acid levels in mesencephalic dopaminergic areas. The effect of nociceptin on the mesencephalic dopaminergic system might explain its actions on motor behavior.

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Citations

Feb 24, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Elaine C Gavioli, Girolamo Calo'
Jul 19, 2006·Cell and Tissue Research·Chiara SalioAdalberto Merighi
Feb 6, 2004·European Journal of Pharmacology·Yukie KawaharaBen H C Westerink
May 15, 2002·European Journal of Pharmacology·Satomi IshiharaToshihiko Murayama
Aug 19, 2003·European Journal of Pharmacology·Jolanta KotlinskaJerzy Silberring
Jan 12, 2002·Peptides·A L Vaccarino, A J Kastin
Apr 12, 2002·Progress in Neurobiology·A Merighi
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Sep 2, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aurelia CesAbdel-Mouttalib Ouagazzal
Aug 7, 2002·British Journal of Pharmacology·Anna SiniscalchiClementina Bianchi
Dec 6, 2002·British Journal of Pharmacology·K FlauE Schlicker
May 29, 2013·Pharmacology & Therapeutics·Elaine Cristina Gavioli, Girolamo Calo'
Jun 16, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·E C GavioliG Calo'
Mar 26, 2009·General and Comparative Endocrinology·Takashi BungoMasanori Fujita
Dec 23, 2008·Neurobiology of Learning and Memory·Celia GoeldnerAbdel-Mouttalib Ouagazzal
Apr 18, 2009·Neuropharmacology·Kazuto Sakoori, Niall P Murphy
Dec 2, 2008·Medical Hypotheses·Norman Brown, Jaak Panksepp
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Jan 13, 2011·Alcoholism, Clinical and Experimental Research·Daina EconomidouRoberto Ciccocioppo
Nov 13, 2010·Cardiovascular Therapeutics·William M Armstead

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