PMID: 10998536Sep 22, 2000Paper

Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system

E Schlicker, Michele Morari


In this article, the effect of nociceptin (orphanin FQ) on transmitter release in the central nervous system in vitro and in vivo is reviewed. Nociceptin inhibits the electrically or K(+)-evoked noradrenaline, dopamine, serotonin, and glutamate release in brain slices from guinea-pig, rat, and mouse. This effect is usually naloxone-resistant but antagonized by OP(4) receptor antagonists like [Phe(1)psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2). In the rat in vivo, nociceptin diminishes acetylcholine release in the striatum, reduces dopamine release, and prevents the stimulatory effect of morphine on this transmitter in the nucleus accumbens and also elevates extracellular glutamate and gamma-aminobutyric acid levels in mesencephalic dopaminergic areas. The effect of nociceptin on the mesencephalic dopaminergic system might explain its actions on motor behavior.


Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Nov 1, 1996·British Journal of Pharmacology·B NicolA T McKnight
Jan 1, 1997·The European Journal of Neuroscience·J SandinL Terenius
Mar 7, 1998·British Journal of Pharmacology·R GuerriniD Regoli
Apr 4, 1998·European Journal of Pharmacology·J C Meunier
Jul 11, 1998·The Journal of Biological Chemistry·Y NodaH Takeshima
Jul 23, 1998·Canadian Journal of Physiology and Pharmacology·J R NicholsonA T McKnight
Aug 1, 1998·European Journal of Pharmacology·H MorikawaK Mori
Oct 17, 1998·European Journal of Pharmacology·B NicolA T McKnight
Nov 24, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerU Bauer
Sep 28, 1999·British Journal of Pharmacology·A SiniscalchiC Bianchi
Oct 30, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·K VaraniD Regoli
Jan 29, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·B MalinowskaE Schlicker
Sep 22, 2000·Peptides·T D MoranP A Smith
Sep 22, 2000·Peptides·S GiulianiC A Maggi
Sep 22, 2000·Peptides·J E Grisel, J S Mogil

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