Nociceptin/orphanin FQ modulates motor behavior and primary motor cortex output through receptors located in substantia nigra reticulata

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Matteo MartiMichele Morari

Abstract

This study was set to investigate whether motor effects of nociceptin/orphanin FQ (N/OFQ) can be related to changes in primary motor cortex output. N/OFQ injected i.c.v. biphasically modulated motor performance, low doses being facilitating and higher ones inhibitory. These effects were counteracted by the N/OFQ receptor antagonist [Nphe(1) Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) confirming the specificity of N/OFQ action. However, UFP-101 alone facilitated motor performance, suggesting that endogenous N/OFQ inhibits motor function. N/OFQ and UFP-101 injected into the substantia nigra reticulata but not motor cortex replicated these effects, suggesting motor responses were mediated by subcortical circuits involving the basal ganglia. Intracortical microstimulation technique showed that i.c.v. N/OFQ also biphasically modulated motor cortex excitability and movement representation. Low N/OFQ doses caused a leftward shift of threshold distribution curve in the forelimb area without affecting the number of effective sites. Conversely, high N/OFQ doses increased unresponsive and reduced excitable (movement) sites in vibrissa but not forelimb area. However, increased threshold currents and rightward shift of threshold distribution curv...Continue Reading

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Citations

Sep 30, 2010·Peptides·Richard J Bodnar
Jul 1, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Matteo MartiMichele Morari
Jul 26, 2015·Progress in Neurobiology·Matthieu F BastideErwan Bézard
Apr 17, 2008·Neurobiology of Disease·Riccardo ViaroMichele Morari
Oct 28, 2019·British Journal of Pharmacology·Daniela MercatelliMichele Morari
Apr 17, 2021·Frontiers in Neuroscience·Joaquim Azevedo NetoGirolamo Calò

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