Nociceptin/orphanin FQ modulates the cardiovascular, but not renal, responses to stress in spontaneously hypertensive rats

Clinical and Experimental Pharmacology & Physiology
Daniel R KapustaVelga A Kenigs

Abstract

1. The central administration of the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) produces marked cardiovascular depressor and renal sympathoinhibitory responses in conscious animals. These findings are evidence that central N/OFQ may modulate the cardiovascular and renal responses to acute environmental stress. 2. The changes in cardiovascular and renal function produced by intracerebroventricular (i.c.v.) N/OFQ were measured in conscious spontaneously hypertensive rats (SHR) under basal conditions and during the acute environmental stimulus of air jet stress. 3. In SHR, central N/OFQ produced profound hypotensive, bradycardic, renal sympathoinhibitory (delayed) and water-diuretic effects by a pathway that does not involve activation of central alpha2-adrenoceptors or classical opioid receptors. 4. Intracerebroventricular injection of N/OFQ prevented the pressor response and blunted the tachycardia to air jet stress. A similar renal sympathoexcitatory and antinatriuretic response was observed in conscious SHR during air stress, before and after i.c.v. N/OFQ. 5. These findings are evidence that, in conscious SHR, i.c.v. N/OFQ selectively inhibited the neural responses to air jet stress by attenuating sympatheti...Continue Reading

References

Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·F JenckO Civelli
Jul 23, 1999·Brain Research·G GriebelD J Sanger
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KösterR K Reinscheid
Nov 24, 1999·The American Journal of Physiology·S F O'brienS T Davidge

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Citations

Feb 24, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Elaine C Gavioli, Girolamo Calo'
Mar 17, 2004·Journal of Neuroimmunology·Paula S WaitsJulie D McLeod
Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Nov 7, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard D Wainford, Daniel R Kapusta
Apr 28, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eduardo Albino Trindade FortalezaFernando Morgan de Aguiar Corrêa
Nov 15, 2011·Stress : the International Journal on the Biology of Stress·Paola NativioFrancesca Passarelli
Jun 7, 2014·Stress : the International Journal on the Biology of Stress·Daniel Gustavo Dos ReisFernando Morgan Aguiar Corrêa
May 29, 2013·Pharmacology & Therapeutics·Elaine Cristina Gavioli, Girolamo Calo'
Nov 20, 2004·Journal of Cardiovascular Pharmacology·Alissa R HicksKurt J Varner
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vineet C Chitravanshi, Hreday N Sapru
Apr 28, 2005·The Journal of Pharmacology and Experimental Therapeutics·Daniel R KapustaVelga A Kenigs
Jan 5, 2021·Frontiers in Cellular Neuroscience·Ashwini HariharanThomas A Longden

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