Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as decrease in hippocampal acetylcholine release in the rat

Brain Research
Masayuki HiramatsuNao Nomura

Abstract

Nociceptin/orphanin FQ is an endogenous neuropeptide that plays important roles in several physiological functions including pain, anxiety, locomotion, learning, and memory. We previously reported that low doses of nociceptin improved the scopolamine-induced impairment of learning and memory in the passive avoidance test and the spontaneous Y-maze alternation task in mice. In the present study, the effects of nociceptin on learning and memory impairment as well as the decrease in acetylcholine release induced by mecamylamine were investigated in rats. Mecamylamine (49 micromol/kg, s.c.), a nicotinic acetylcholine receptor antagonist, impaired learning and memory in the step-through type passive avoidance test and decreased acetylcholine release in the hippocampus, as determined by in vivo microdialysis. The administration of nociceptin (10 fmol/rat, i.c.v.) reversed the impairment of learning and memory and blocked the decrease in acetylcholine release induced by mecamylamine. This ameliorating effect on the mecamylamine-induced impairment of learning and memory was not blocked by [NPhe(1)]nociceptin(1-13)NH(2) (1 nmol/rat, i.c.v.), an opioid receptor-like 1 (NOP) receptor antagonist. These results suggest that nociceptin impro...Continue Reading

References

Jan 1, 1993·Annual Review of Neuroscience·P B Sargent
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·H P NothackerO Civelli
Nov 1, 1996·British Journal of Pharmacology·B NicolA T McKnight
Jan 13, 1997·Biochemical and Biophysical Research Communications·J P MathisG W Pasternak
Jan 1, 1997·The European Journal of Neuroscience·J SandinL Terenius
Mar 17, 1999·European Journal of Pharmacology·M Hiramatsu, K Inoue
Apr 1, 2000·British Journal of Pharmacology·G Calo'D Regoli
Mar 22, 2002·The European Journal of Neuroscience·G A HigginsA J Grottick
Dec 10, 2003·British Journal of Pharmacology·Alexander KuzminSven Ove Ogren
Jun 28, 2005·Brain Research·Kayoko UezuYusuke Morita

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Citations

Dec 9, 2008·European Journal of Pharmacology·Masaya MiwaMasayuki Hiramatsu
Mar 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Raül Andero
Jun 19, 2013·Physiology & Behavior·Mohammad-Reza ZarrindastAmeneh Rezayof
Oct 2, 2009·Peptides·Richard J Bodnar

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