Nociceptive sensitivity/behavioral reactivity regulation in rats during aversive states of different nature: its mediation by opioid peptides

The International Journal of Neuroscience
E A Kiyatkin

Abstract

To study the regulation of nociceptive sensitivity/behavioral reactivity in animals during aversive states of different nature, the changes of vocalization thresholds and tail-withdrawal latencies were investigated in rats in free behavior, during restraint stress, after acute trauma to an extremity and under intraperitoneal acetic acid administration. To understand opioid peptide involvement in mediation of the changes obtained, this analysis was also done during opiate receptor blockade by naloxone. The data on the modification of vocalization and movement reactivity as well as on the changes of suprarenal weight and gastric ulceration, produced in normal and naloxone-treated rats by innoxious stressogenic, noxious somatic and visceral stimulation are discussed in relation with: 1. the peculiarities of sensitivity and responsivity of animals to external stimuli in aversive environment; 2. the role of these changes in maintenance of an animal's adaptive activity produced by environmental threat and their mediation by endogenous opioids; 3. the functional significance of the activation of endogenous opioidergic neurotransmission in organization, realization and modification of an animal's adaptive activity, directed on behavior...Continue Reading

References

Apr 27, 1978·Nature·J D LevineH L Fields
Mar 26, 1979·Life Sciences·J J CarmodyD Morgans
Sep 15, 1979·European Journal of Pharmacology·W R Buckett
Sep 3, 1979·Life Sciences·R McGivernC A Sandman
Jun 5, 1978·Life Sciences·M B BassD Lester
Oct 1, 1977·Life Sciences·N Kokka, A S Fairhurst
Oct 16, 1987·Neuroscience Letters·G ForsbergP Södersten
Apr 1, 1987·Biulleten' eksperimental'noĭ biologii i meditsiny·E V GolanovS B Parin
Mar 9, 1987·Neuroscience Letters·J Carmody, K Cooper
Jan 1, 1987·Physiology & Behavior·L D Matzel, R R Miller
Apr 1, 1987·Biulleten' eksperimental'noĭ biologii i meditsiny·K V MashilovV V Rozhanets
Jan 1, 1986·Physiology & Behavior·R J Rodgers, J I Randall
Jul 15, 1986·European Journal of Pharmacology·F V AbbottB Connell
Aug 19, 1985·Brain Research·G Urca, A Nof-Reshef
Feb 1, 1985·Neuropharmacology·J R Naranjo, J A Fuentes
Apr 1, 1985·Pain·B Whipple, B R Komisaruk
May 1, 1985·Pharmacology, Biochemistry, and Behavior·A F ArnstenD S Segal
May 1, 1985·Pharmacology, Biochemistry, and Behavior·M N Girardot, F A Holloway
Nov 19, 1965·Science·R Melzack, P D Wall
Aug 1, 1966·Genetical Research·W D Donachie, M Masters
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·S AmirZ Amit
Mar 26, 1981·European Journal of Pharmacology·H SzechtmanR Simantov
Jan 1, 1982·Annual Review of Psychology·R C Bolles, M S Fanselow

❮ Previous
Next ❯

Citations

Jul 3, 1990·European Journal of Pharmacology·J C WillerT De Broucker
May 1, 1991·The International Journal of Neuroscience·E A Kiyatkin, V N Zhukov
May 10, 2011·Physiology & Behavior·Erin N Umberg, Emmanuel N Pothos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.