Nociceptive somatic nerve stimulation and skeletal muscle injury modify systemic hemodynamics and oxygen transport and utilization after resuscitation from hemorrhage

Critical Care Medicine
M Y RadyR A Little

Abstract

To examine if either nociceptive somatic nerve stimulation or skeletal muscle injury modified systemic hemodynamics and oxygen transport and utilization after resuscitation from hemorrhage in anesthetized pigs. Prospective, randomized, controlled laboratory study. Animal laboratory. Twenty isoflurane-anesthetized and mechanically ventilated large white pigs. Three groups of animals were instrumented with femoral arterial and thermodilution pulmonary artery catheters. One group of animals had bilateral brachial nerve electric stimulation before hemorrhage (brachial nerve stimulation + hemorrhage, n = 7). The second group of animals had bilateral hindlimbs skeletal muscle injury induced by firing a captive-bolt handgun with standard charges before hemorrhage (skeletal muscle injury + hemorrhage, n = 6). The third group had neither insult before hemorrhage (control, n = 7). Controlled bleeding was initiated to reduce the cardiac index and systemic oxygen delivery (Do2) by 50% in all animals. Animals were then left for 30 mins before resuscitation. All animals were resuscitated with 4.5% human serum albumin at 45 mL/kg and observed for 2 hrs. Plasma volume, systemic hemodynamics, and oxygen transport variables were measured and cal...Continue Reading

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Citations

Mar 13, 2002·Critical Care Medicine·Anna GirolamiPaul M Dark
Dec 17, 2009·Clinical Orthopaedics and Related Research·Nikolaos G LasanianosPeter V Giannoudis
May 25, 2006·The Journal of Bone and Joint Surgery. British Volume·T O WhiteC M Robinson
Oct 29, 2008·Journal of Korean Medical Science·Chang Seok KimKi Jun Kim

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