Nociceptor subpopulations involved in hyperalgesic priming.

Neuroscience
L F FerrariJ D Levine

Abstract

We have previously developed a model in the rat for the transition from acute to chronic pain, hyperalgesic priming, in which a long-lasting neuroplastic change in signaling pathways mediates a prolongation of proinflammatory cytokine-induced nociceptor sensitization and mechanical hyperalgesia, induced at the site of a previous inflammatory insult. Induction of priming is mediated by activation of protein kinase C(epsilon) (PKC(epsilon)) in the peripheral terminal of the primary afferent nociceptor. Given that hyperalgesic mediator-induced PKC(epsilon) translocation occurs in isolectin B4 (IB4)(+)-nonpeptidergic but not in receptor tyrosine kinase (TrkA)(+)-peptidergic nociceptors, we tested the hypothesis that hyperalgesic priming was restricted to the IB4(+) subpopulation of nociceptors. After recovery from nerve growth factor (NGF)- and GDNF-induced hyperalgesia, a proinflammatory cytokine, prostaglandin E(2) (PGE(2)) induced, PKC(epsilon)-dependent, markedly prolonged hyperalgesia, two features that define the development of the primed state. Thus, hyperalgesic priming occurs in both the IB4(+)-nonpeptidergic and TrkA(+)-peptidergic subpopulations of nociceptive afferents. Of note, however, while attenuation of PKC(epsilon...Continue Reading

References

Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·C LehelW B Anderson
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·D RonD Mochly-Rosen
Mar 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S B McMahon
Aug 7, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·D L Bennett
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tim B HuchoJon D Levine
Jul 20, 2005·The European Journal of Neuroscience·Misbah Malik-HallJon D Levine
Mar 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kathryn M AlbersH Richard Koerber
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sacha A MalinBrian M Davis
Dec 13, 2006·The Journal of Pain : Official Journal of the American Pain Society·Gretchen J SummerJon D Levine
Aug 19, 2008·Journal of Neuroscience Research·Tomoko WatanabeToshihide Yamashita
Sep 29, 2009·Trends in Neurosciences·David B Reichling, Jon D Levine

❮ Previous
Next ❯

Citations

Aug 24, 2012·Journal of Neurophysiology·Pedro AlvarezJon D Levine
Nov 16, 2013·The Journal of Clinical Investigation·Huijing WangAnnemieke Kavelaars
Apr 28, 2011·Neurosurgery·Yan Michael Li, Walter A Hall
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luiz F FerrariJon D Levine
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luiz F FerrariJon D Levine
Aug 16, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J SchusterGeorge L Wilcox
Feb 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oliver BogenJon D Levine
Mar 8, 2014·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Joseph V PergolizziRobert Taylor
Jan 2, 2016·The Journal of Pain : Official Journal of the American Pain Society·Lindsay B ConnerJon D Levine
Aug 26, 2014·Neurobiology of Disease·R P HulseL F Donaldson
Jan 17, 2014·Expert Opinion on Drug Metabolism & Toxicology·Haitao YangXu Steven Xu
Nov 21, 2015·Pain·Dioneia AraldiJon D Levine
May 15, 2013·The Journal of Pain : Official Journal of the American Pain Society·Luiz F FerrariJon D Levine
Feb 15, 2012·The Ocular Surface·Perry Rosenthal, David Borsook
Aug 27, 2013·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Robert B Raffa, Joseph V Pergolizzi
May 12, 2010·Neuroscience·E K Joseph, J D Levine
Feb 6, 2013·The European Journal of Neuroscience·Luiz F FerrariJon D Levine
Apr 8, 2015·Journal of Neurochemistry·Oliver BogenFerdinand Hucho
Jan 11, 2014·The Journal of Pain : Official Journal of the American Pain Society·Luiz F FerrariJon D Levine
Dec 31, 2011·Experimental Neurology·Pedro AlvarezJon D Levine
Jun 20, 2013·Pain·Wilfrid Jänig
Dec 3, 2014·The Journal of Pain : Official Journal of the American Pain Society·Luiz F Ferrari, Jon D Levine
Nov 26, 2015·Journal of Dental Research·W H Sun, C C Chen
Sep 5, 2020·Journal of Neurochemistry·Anibal Garza CarbajalTim Hucho
Jun 21, 2018·Frontiers in Pharmacology·Hui-Jing WangAnnemieke Kavelaars
Oct 6, 2011·Anaesthesia and Intensive Care·E A Shipton
Jan 29, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Liang-Ta YenYi-Wen Lin
May 29, 2021·Endocrinology·Melissa E LenertMichael D Burton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Related Papers

Trends in Neurosciences
D B Reichling, Jon D Levine
The Journal of Pain : Official Journal of the American Pain Society
Luiz F FerrariJon D Levine
The European Journal of Neuroscience
L F FerrariJon D Levine
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Elizabeth K JosephJon D Levine
© 2022 Meta ULC. All rights reserved