Nocturia and associated mortality: observational data from the REDUCE trial

Prostate Cancer and Prostatic Diseases
Donald L BliwiseStephen J Freedland

Abstract

Nocturia (voids arising from sleep) is a ubiquitous phenomenon reflecting many diverse conditions but whether it has significance in its own right remains uncertain. We examined whether nocturia was an independent risk factor for mortality METHODS: These were observational analyses employing primarily North American and European participants and included 7343 men, aged 50-75 years participating in the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) trial. Cox proportional hazards models were used to test the association between baseline nocturia (voiding ≥3 times per night) and all-cause mortality. Potential confounding variables included: age; race; region of origin; treatment group; self-reported coronary artery disease, diabetes mellitus, hypertension, and peripheral vascular disease; smoking; alcohol use; prostate volume; and diuretics. Self-reported sleep quality, as measured with the Medical Outcomes Study sleep scale, was entered as a final step in the model. Nocturia was associated with increased mortality risk (hazard ratio [HR] = 1.72; 95% CI 1.15-2.55) independent from demographics and medical comorbidities. Inclusion of disturbed sleep in the model reduced the magnitude of the association (HR = 1.43; 95%...Continue Reading

References

Dec 1, 1992·Journal of the American Geriatrics Society·R B StewartW E Hale
Jun 1, 1992·Scandinavian Journal of Primary Health Care·R Asplund, H Aberg
May 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H A MiddelkoopC P Springer
Feb 25, 1998·Journal of the American Geriatrics Society·S MaggiG Enzi
Sep 1, 1999·BJU International·R Asplund
Oct 19, 2000·Journal of the American Geriatrics Society·G S BrassingtonD L Bliwise
Nov 18, 2003·BJU International·A RembrattK-E Andersson
Mar 5, 2004·Sleep·Mary Grace UmlaufDennis J Pillion
May 19, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Koji YoshimuraYoichi Arai
May 27, 2004·Journal of the American Geriatrics Society·Yohannes W EndeshawDonald L Bliwise
Feb 1, 2005·Sleep Medicine·Ron D HaysKaren L Spritzer
May 10, 2005·Journal of the American Geriatrics Society·Theodore M JohnsonPatricia S Goode
Jun 7, 2005·Journal of the American Geriatrics Society·Alon Y AvidanRonald D Chervin
Jan 13, 2006·The Journal of Urology·Kari A O TikkinenAnssi Auvinen
Feb 7, 2006·Archives of Gerontology and Geriatrics·R Asplund
Feb 14, 2006·BJU International·Luba W GourovaPhilip E V A van Kerrebroeck
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Mary P FitzgeraldSairam Parthasarathy
Dec 1, 2006·The American Journal of Cardiology·Michael BursztynJochanan Stessman
Feb 16, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elizabeth Latimer HillDavid G Le Couteur
Mar 27, 2007·The Journal of Urology·Mary P FitzgeraldUNKNOWN BACH Survey Investigators
Aug 16, 2008·Sleep Medicine·Donald L BliwiseJames K Walsh
Sep 10, 2008·Archives of Internal Medicine·Katie L StoneSteven R Cummings
Jan 22, 2009·BJU International·J Kellogg ParsonsLynn M Marshall
Mar 21, 2009·Neurourology and Urodynamics·Christian TemmlStephan Madersbacher
Jun 12, 2009·American Journal of Epidemiology·Kari A O TikkinenTeuvo L J Tammela
Apr 2, 2010·The New England Journal of Medicine·Gerald L AndrioleUNKNOWN REDUCE Study Group
May 12, 2010·International Journal of Clinical Practice·C P VaughanT M Johnson
Jul 16, 2010·Journal of Sleep Research·Arthur Eumann MesasFernando Rodríguez-Artalejo
Sep 29, 2011·European Urology·Varant KupelianJohn B McKinlay
Jan 12, 2012·BJU International·Deborah J LightnerJennifer L St Sauver
Feb 9, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jean-Alfred ThomasStephen J Freedland
Mar 20, 2012·The Journal of Urology·Boris van DoornJ L H Ruud Bosch
Jul 6, 2012·Journal of the American Medical Directors Association·Gianluigi GaliziaPasquale Abete
Mar 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Jamie M ZeitzerJerome A Yesavage

❮ Previous
Next ❯

Citations

Apr 7, 2020·Neurourology and Urodynamics·J Quentin ClemensUNKNOWN LURN Study Group
Aug 25, 2020·The Prostate·Emily K WigginsEmma H Allott
Jan 23, 2020·Journal of Clinical Psychology in Medical Settings·Donald L BliwiseStephen J Freedland
Nov 30, 2018·Prostate Cancer and Prostatic Diseases·Vincent MisraïAtul Pathak
Nov 25, 2020·Drugs & Aging·Dylan T WolffJeffrey P Weiss
Jul 17, 2019·Urology·Donald L BliwisePeter K Sand
Jun 20, 2021·Neurourology and Urodynamics·Donald L Bliwise

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary bypass
biopsy

Software Mentioned

STATA
REDUCE

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.