Abstract
Abnormal circadian rhythm of blood pressure (BP) is closely related to target organ damage in hypertension. However, the association between abnormal circadian rhythm of BP and renal injury is not clear. We investigated whether renal injury is associated with nocturnal BP and circadian rhythm of BP in Chinese IgAN patients. Clinic and 24 h ambulatory BP monitoring data were obtained from 330 Chinese IgAN patients with mean 24 h BP < 130/80 and mean daytime BP < 135/85 mmHg. Renal histopathological injury was determined according to the Oxford classification of IgAN. Among the 330 IgAN subjects, 35.8% suffered from nocturnal hypertension, 61.5% had abnormal circadian BP, and 27% had nocturnal hypertension with a nondipping pattern. Compared with nocturnal normotensive patients, patients with nocturnal hypertension had significantly higher levels of blood cystatin C, blood uric acid, and lower estimated glomerular filtration rate (eGFR), and significantly a higher mean renal tissue injury score. The nondipping hypertensive group had significantly higher nocturnal diastolic and systolic BP, blood uric acid, and glomerulosclerosis rates, whereas eGFR was lower. In nondipping hypertensive patients, urinary sodium excretion and renal...Continue Reading
References
Mar 3, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B CsikyJ Nagy
Feb 5, 2000·Nephron·J MeraM Nagase
Aug 26, 2004·Kidney International·Lei-Shi Li, Zhi-Hong Liu
Feb 11, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jie WuGuangyan Cai
Feb 10, 2006·Kidney International·R Agarwal, M J Andersen
Mar 19, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Emin AliogluMustafa Akin
Dec 17, 2008·Archives of Gerontology and Geriatrics·A AmiciM Cacciafesta
Jan 28, 2009·Hypertension·Alejandro de la SierraUNKNOWN Spanish Society of Hypertension Ambulatory Blood Pressure Monitoring Registry Investigators
Mar 19, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Ahmet SoyluHasan Gok
Mar 21, 2009·Current Opinion in Nephrology and Hypertension·Candice A Roufosse, H Terence Cook
Jun 13, 2009·American Journal of Nephrology·Guang-Yan Cai, Xiang-Mei Chen
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Sep 5, 2009·Nephron. Clinical Practice·Sun Moon KimChun Soo Lim
Jan 22, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Michael WalshBrenda Hemmelgarn
Feb 13, 2010·Journal of Hypertension·Josep RedonFernando Martinez
Jun 19, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A StevensAndrew S Levey
Oct 26, 2010·Chronobiology International·Francesco PortaluppiYvan Touitou
Mar 5, 2011·American Journal of Nephrology·Costas TsioufisChristodoulos Stefanadis
Jun 29, 2011·Archives of Internal Medicine·Roberto MinutoloLuca De Nicola
Mar 21, 2012·Nature Reviews. Nephrology·Kar Neng Lai
Oct 9, 2012·Chronobiology International·Ramón C HermidaJosé R Fernández
Oct 19, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tatsuo KawaiHiromi Rakugi
Nov 28, 2012·Chronobiology International·Artemio MojónUNKNOWN Hygia Project Investigators
Feb 9, 2013·PloS One·Cheng WangTanqi Lou
Feb 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Satoshi IimuroUNKNOWN Chronic Kidney Disease Japan Cohort Study Group
Mar 23, 2013·Chronobiology International·Ramón C HermidaFrancesco Portaluppi
May 29, 2013·Clinical and Experimental Pharmacology & Physiology·Cara J Büsst
Jun 21, 2013·The New England Journal of Medicine·Robert J Wyatt, Bruce A Julian
Sep 26, 2013·American Journal of Hypertension·Alejandro de la SierraLuis M Ruilope
Citations
Jul 14, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shinsuke IsobeHideo Yasuda
Feb 2, 2018·International Journal of Molecular Sciences·Asadur RahmanHiroyuki Kobori
Mar 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naro OhashiHideo Yasuda
Nov 3, 2017·PloS One·Koji InagakiShoichi Maruyama
Oct 10, 2018·Clinical and Experimental Hypertension : CHE·Jingru LinFei Zheng
Aug 26, 2018·Nature Reviews. Nephrology·Dmitri Firsov, Olivier Bonny
Jun 24, 2020·Der Internist·J SchraderM Middeke
Nov 26, 2020·Medicine·Zhi-Feng LuoWei-Guo Sui