Nocturnal antral pH rises are related to duodenal phase III retroperistalsis

Digestive Diseases and Sciences
E S Björnsson, H Abrahamsson

Abstract

The mechanisms behind nocturnal rises of gastric pH are unknown. We have analyzed the relation between interdigestive duodenal peristalsis and nocturnal pH in the gastric antrum. Simultaneous recording of antroduodenal pressures and intragastric pH was performed in 11 healthy subjects (six men, five women) overnight for 8 hr, using a catheter with seven pressure recording points and an antral glass pH electrode. Three pressure recording sites were closely spaced in the descending duodenum. Altogether 46 phase III activities were recorded. A retroperistaltic sequence in the last part of phase III was observed in 31 phase III activities (67.4%), while 15 phase III activities lacked retroperistalsis. All subjects had retroperistalsis in at least one phase III at night with a median of 60% (52-100%) (interquartile range). The duration of the whole phase III was 5.1 (3.1-7.0) min, whereas the duration of the retroperistaltic period was 2.0 (1.5-3.2) min, corresponding to 45% (23-64%) of the duration of phase III. The peak of antral pH occurred 7.4 (6.0-13.0) min from the start of the phase III in the duodenum and and the rise in pH lasted for 8.0 (4.8-12.0) min. Measurement of pH for a period of 10 min before and after phase III, de...Continue Reading

Citations

Jul 27, 2001·Alimentary Pharmacology & Therapeutics·W K FacklerJ E Richter
Aug 23, 2005·Digestive Diseases and Sciences·Guillaume SavoyeAndré Smout
Feb 6, 1999·The American Journal of Gastroenterology·E S Björnsson, H Abrahamsson
May 3, 2000·Alimentary Pharmacology & Therapeutics·M CastedalH Abrahamsson
Nov 8, 2003·World Journal of Gastroenterology : WJG·Jin-Yan LuoJun Gong
Dec 20, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·G SavoyeA J P M Smout
Nov 1, 2006·Journal of Gastroenterology and Hepatology·Kyoko InoMasatomo Mori
Mar 24, 2015·Scandinavian Journal of Gastroenterology·Hans TörnblomHasse Abrahamsson
Apr 11, 2015·Gastroenterology Research and Practice·Alastair M SammonJehu E Iputo
Nov 7, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Castedal, H Abrahamsson
Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G H KoekJ Tack
Apr 15, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T TsubukuT Yanagawa

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