Nocturnal dipping status and the association of morning blood pressure surge with subclinical target organ damage in untreated hypertensives

The Journal of Clinical Hypertension
Shenzhen GongXiaoping Chen

Abstract

The authors aimed to investigate the association between sleep-through morning surge (MS) in blood pressure (BP) and subclinical target organ damage in untreated hypertensives with different nocturnal dipping status. This cross-sectional study included 1252 individuals who underwent anthropometric measurements, serum biochemistry evaluation, 24-hour ambulatory blood pressure monitoring, echocardiography, and carotid ultrasonography. Left ventricular mass index, left atrial dimension, and carotid intima-media thickness were evaluated. Participants were grouped according to nocturnal systolic BP dipping rate (388 dippers, 10%-20%; 674 non-dippers, 0%-10%; 190 reverse dippers, <0%). Twenty-two extreme dippers were excluded. While reverse dippers exhibited the most severe signs of damage, only dippers showed significant and positive correlation between MS and hypertension-mediated organ damage (all P < .05), with significant area under the receiver operating characteristic curve for discriminating left ventricular hypertrophy (0.662), left atrial enlargement (0.604), and carotid intima-media thickening (left, 0.758; right, 0.726; all P < .05). MS showed significant association with subclinical organ damage on both logistic and mult...Continue Reading

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Citations

Aug 4, 2019·The Journal of Clinical Hypertension·Kouichi TamuraHiromichi Wakui
Dec 14, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Domenico Di RaimondoAntonio Pinto
Feb 4, 2021·Journal of Sleep Research·Lourdes M DelRossoRaffaele Ferri
Oct 16, 2020·The Journal of Clinical Hypertension·Shiniya Taguchi, Kouichi Tamura
Feb 17, 2021·The Journal of Clinical Hypertension·Natalia Burgos-AlonsoGonzalo Grandes
Jul 30, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keisuke NaritaKazuomi Kario

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