PMID: 9187908Jan 1, 1997Paper

Nocturnal enuresis and daytime wetting: a multicentric trial with oxybutynin and desmopressin

European Urology
Paolo CaioneW Artibani

Abstract

Different etiopathological mechanisms of enuresis are today under study, and different therapies and drugs have been proposed. The Italian Multicentric Trial was undertaken in twelve pediatric and urological centers in order to assess the efficacy of two of the most popular drugs, desmopressin (DDAVP) and oxybutynin. 114 enuretic patients were enrolled in the study. After a 2-week observation period, 66 patients with primary monosymptomatic enuresis were treated with DDAVP, 30 micrograms/day intranasally, for 6 weeks, 48 patients with enuresis and voiding dysfunction were randomly assigned to a protocol with oxybutynin alone or oxybutynin plus DDAVP. The efficacy of the two drugs was measured in terms of reduction of wet nights per week during the 6-week treatment period and a 2-week follow-up period. Children with 0-3 dry nights/week were considered as nonresponders. Patients with monosymptomatic enuresis treated with DDAVP reported a significantly lower number of wet night during treatment than during the baseline period, with 79% showing a 'good' (6-7 dry nights/week) or 'intermediate' response (4-5 dry nights/week). Of the patients with diurnal voiding disturbances and enuresis, those treated with oxybutynin alone had a 54%...Continue Reading

Citations

Nov 24, 1999·The Journal of Urology·T NevéusA Stenberg
Jan 5, 2002·Scandinavian Journal of Urology and Nephrology·R J Butler
Jul 26, 2002·The Cochrane Database of Systematic Reviews·C M Glazener, J H Evans
Dec 18, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cherry Fai-Ngo NgUNKNOWN Hong Kong Childhood Enuresis Study Group
Nov 16, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tryggve Nevéus, Kjell Tullus
Jul 6, 2000·Clinical Pediatrics·S L SchulmanC Kodman-Jones
Dec 21, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Hisashi HonjoTsuneharu Miki
Oct 29, 2003·British Journal of Community Nursing·A Sahib El-Radhi, Christine Board
Aug 21, 2007·The Journal of Urology·Boris ChertinAmicur Farkas
Jun 19, 2004·Scandinavian Journal of Urology and Nephrology·Richard J ButlerDiane Doherty-Williams
Jan 31, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Se Jin ParkUNKNOWN Korean Children’s Continence and Enuresis Society
May 1, 2004·The Journal of Urology·Arne-Daniela Marschall-KehrelHelmut Madersbacher
Mar 10, 2004·Current Medical Research and Opinion·Sidney B RadomskiAndrew C Darke
Nov 30, 2000·Scandinavian Journal of Urology and Nephrology·R J Butler, P Holland
May 1, 2004·The Journal of Urology·Jack S Elder
Sep 1, 2009·Expert Review of Endocrinology & Metabolism·Paul F Austin
Nov 7, 2001·The Journal of Urology·T Nevéus
May 5, 2000·The Cochrane Database of Systematic Reviews·C M Glazener, J H Evans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.