Nocturnal growth hormone (GH) secretion is eliminated by infusion of GH-releasing hormone antagonist

The Journal of Clinical Endocrinology and Metabolism
B Ocampo-LimC A Jaffe

Abstract

The neuroendocrine mechanisms underlying the generation of pulsatile GH secretion in humans are poorly understood. GH secretory pulses are likely to result from acute GHRH secretory episodes, acute decreases in hypothalamic somatostatin secretion, or a combination of these mechanisms. In earlier studies we demonstrated that a single i.v. bolus of a competitive GHRH antagonist [N-Ac-Tyr1,D-Arg2)GHRH-(1-29); GHRH-Ant] blocked 40% of the nocturnal GH release. Failure to more completely eliminate nocturnal GH secretion could be due to either incomplete antagonism of endogenous GHRH action by GHRH-Ant or a non-GHRH component of GH release. We subsequently investigated whether a continuous infusion of GHRH-Ant would more completely eliminate nocturnal GH secretion. Eight men were given a 400 micrograms/kg i.v. bolus of GHRH-Ant at 2300 h, followed by a 50 micrograms/kg.h i.v. infusion of GHRH-Ant between 2300-0700 h or a saline bolus followed by a saline infusion. An i.v. bolus of GHRH (1 microgram/kg) was given at 0500 h on both occasions. Blood was sampled every 10 min between 2300-0700 h. As measured by the area under the curve (AUC) from 2400-0500 h, GHRH-Ant suppressed GH secretion by an average of 89% (1795 +/- 412 vs. 164 +/- ...Continue Reading

Citations

Sep 6, 2012·The Journal of Clinical Endocrinology and Metabolism·N D ShawJ E Hall
Apr 27, 2010·Journal of Endocrinological Investigation·F LanfrancoM Maccario
Jul 18, 2006·Pituitary·Sowmya SuryaAriel L Barkan
Oct 3, 2015·PloS One·Eirini KallioliaThomas T Warner
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Ken H DarzyStephen M Shalet
Apr 3, 2003·American Journal of Physiology. Endocrinology and Metabolism·Eleni V DimarakiAriel L Barkan
Sep 1, 1999·Clinical Endocrinology·S Chappel

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