Nocturnal home hemodialysis associates with improvement of electrocardiographic features linked to sudden cardiac death

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Benjamin K A ThomsonRobert M Lindsay

Abstract

Sudden cardiac death (SCD) remains the leading cause of death in hemodialysis patients. We performed a retrospective electrocardiograph (ECG) and chart review to determine whether hemodialysis modality, frequency, or duration could predict change in ECG parameters associated with SCD. Frequent nocturnal hemodialysis was associated with an improvement in Tpeak to Tend within 365 days (83.8-71.8 ms, p = 0.005) and past 365 days of dialysis initiation (85.9-77.1 ms, p = 0.005) and improvement in QRS amplitude variation within 365 days (0.0583-0.0297, p = 0.025) and past 365 days of dialysis initiation (0.0546-0.0332, p = 0.029). Compared with intermittent conventional hemodialysis, more frequent nocturnal (15/25 vs. 3/14, p = 0.04) and intermittent nocturnal hemodialysis (INHD) (6/8 vs. 3/14, p = 0.03) patients decreased Tpeak to Tend. More short-hours daily than INHD patients increased T-wave amplitude variation (16/25 vs. 1/8, p = 0.02). These improvements occurred before changes in Cornell or Sokolow-Lyon electrocardiographic left ventricular mass. Thus, it appears that hemodialysis modalities of longer duration are associated with improvements in electrocardiographic parameters associated with SCD. Prospective trials are requi...Continue Reading

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Citations

Nov 14, 2014·Journal of Nephrology·D ZachariahPaul R Roberts
Oct 28, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·John P ForanPaul A Sobotka
Feb 3, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joonas RautavaaraTuomo Nieminen
Apr 3, 2020·Current Vascular Pharmacology·Athanasios RoumeliotisAndreas Pierratos

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