Nocturnal hypoventilation in neuromuscular disease: prevalence according to different definitions issued from the literature

Sleep & Breathing = Schlaf & Atmung
Adam OgnaDavid Orlikowski

Abstract

Restrictive respiratory failure is a major cause of morbidity and mortality in neuromuscular diseases (NMD). Home mechanical ventilation (HMV) is used to treat hypoventilation, identified by daytime hypercapnia or nocturnal desaturation. Recently, transcutaneous measure of CO2 (TcCO2) has been increasingly used to detect hypoventilation, using different cut-offs. We aimed to compare the prevalence of hypoventilation in an unselected adult NMD population according to different definitions issued from the literature. All consecutive nocturnal capno-oximetries performed between 2010 and 2014 in unventilated adult NMD patients were analysed retrospectively. Concomitant blood gas analysis and lung function data were collected. Patients on oxygen therapy were excluded. Hypoventilation was defined according to eight criteria, based on daytime PaCO2, daytime base excess, nocturnal SpO2 or TcCO2. Data from 232 patients were analysed (mean age 43.1 ± 15.4 years; 50.0 % women; vital capacity 59.2 ± 24.2 % of predicted). The hypoventilation prevalence was 10.3 to 61.2 %, depending on the used definition. The different definitions showed 49.1 to 94.8 % concordance (Cohen's kappa for agreement 0.115 to 0.763). Overall agreement between the e...Continue Reading

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Citations

Jan 3, 2016·Paediatric Respiratory Reviews·Alessandro Amaddeo, Brigitte Fauroux
Jul 18, 2016·The Lancet. Respiratory Medicine·Alessandro AmaddeoBrigitte Fauroux
May 26, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Adelle S JeeAmanda Piper
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Dec 7, 2017·The Journal of International Medical Research·Federica TruccoCarlo Minetti
Oct 22, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Matthias BoentertPeter Young
Dec 5, 2019·Multidisciplinary Respiratory Medicine·Paolo BanfiJohn Bach
Jun 1, 2017·Current Opinion in Neurology·Matthias BoentertValeria A Sansone
Apr 27, 2019·Sleep & Breathing = Schlaf & Atmung·Maya RunteMatthias Boentert
May 29, 2020·Current Neurology and Neuroscience Reports·Matthias Boentert
Jan 18, 2020·Pulmonary Medicine·Athanasios VoulgarisPaschalis Steiropoulos
Jul 14, 2017·Sleep & Breathing = Schlaf & Atmung·Mohamad Ammar AlbdewiRiëm El Tahry
Sep 27, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Walter T McNicholasLudger Grote
Dec 3, 2020·Sleep & Breathing = Schlaf & Atmung·Anna Christina MeyerMatthias Boentert
Dec 18, 2020·Frontiers in Pediatrics·Brigitte FaurouxAlessandro Amaddeo
Sep 3, 2021·Pneumologie·Jens GottliebThomas Fühner
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Dec 11, 2020·Respiration; International Review of Thoracic Diseases·Jean-Paul JanssensUNKNOWN on behalf of the Special Interest Group on Ventilation and Oxygen Therapy of the Swiss Society of Pneumology

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