PMID: 2117190Jan 1, 1990Paper

Nocturnal hypoxemia and long-term oxygen therapy in COPD patients with daytime PaO2 60-70 mmHg

Lung
P Levi-ValensiZ Rida

Abstract

Six European treatment centers contributed to a controlled trial to study nocturnal hypoxemia in COPD patients having daytime PaO2 of 60-70 mmHg. The trial is composed of two parts: first, patients inclusion, taking men aged under 70 years, excluding sleep apnea syndrome and all other concomitant pathologies leading to nocturnal desaturation. We described this population and determined the frequency and degree of nocturnal desaturation. Correlations between different daytime and sleep parameters have also been established. The second part concerns the study of the two sub-populations of nocturnal desaturators and nondesaturators. This is followed by random allocation of the desaturators to oxygen or no oxygen treatment. We defined significant nocturnal desaturation as cumulated unsaturation period, exceeding 30% of total time, in bed spent under SaO2 lower than 90%. Twenty out of 46 patients were desaturators (43%). Only the first part is dealt with in this article.

References

Feb 1, 1979·Chest·A J BlockJ W Wynne
Aug 1, 1988·The American Review of Respiratory Disease·J J ConnaughtonN J Douglas
Jul 1, 1983·The American Review of Respiratory Disease·J R CatterallD C Flenley

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Citations

May 17, 2000·Current Opinion in Pulmonary Medicine·J Zieliński
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Oreste MarroneGiuseppe Insalaco
Apr 18, 2014·Multidisciplinary Respiratory Medicine·Seigo MinamiKiyoshi Komuta
Mar 25, 2017·COPD·Jean-Michel ArnalAude Garnero
Dec 12, 2020·Respiratory Research·Marjolaine GeorgesPhilippe Bonniaud
Aug 11, 1991·Chest·R H GrovesS E Buchalter

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